BDBM50249528 2-(4-allyl-5-((phenylamino)methyl)-4H-1,2,4-triazol-3-ylthio)-N'-(5-bromo-2-hydroxybenzylidene)propanehydrazide::CHEMBL470722

SMILES: CC(Sc1nnc(CNc2ccccc2)n1CC=C)C(=O)NN=Cc1cc(Br)ccc1O

InChI Key: InChIKey=QLTGOVCHIBKWSM-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50249528   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Mus musculus (mouse))	BDBM50249528 (2-(4-allyl-5-((phenylamino)methyl)-4H-1,2,4-triazo...) Show SMILES CC(Sc1nnc(CNc2ccccc2)n1CC=C)C(=O)NN=Cc1cc(Br)ccc1O |w:23.25| Show InChI InChI=1S/C22H23BrN6O2S/c1-3-11-29-20(14-24-18-7-5-4-6-8-18)26-28-22(29)32-15(2)21(31)27-25-13-16-12-17(23)9-10-19(16)30/h3-10,12-13,15,24,30H,1,11,14H2,2H3,(H,27,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Materia Medica Curated by ChEMBL					Assay Description Inhibition of mouse 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay in...				Eur J Med Chem 44: 1167-71 (2009) Article DOI: 10.1016/j.ejmech.2008.06.005 BindingDB Entry DOI: 10.7270/Q2251J0Z
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50249528 (2-(4-allyl-5-((phenylamino)methyl)-4H-1,2,4-triazo...) Show SMILES CC(Sc1nnc(CNc2ccccc2)n1CC=C)C(=O)NN=Cc1cc(Br)ccc1O |w:23.25| Show InChI InChI=1S/C22H23BrN6O2S/c1-3-11-29-20(14-24-18-7-5-4-6-8-18)26-28-22(29)32-15(2)21(31)27-25-13-16-12-17(23)9-10-19(16)30/h3-10,12-13,15,24,30H,1,11,14H2,2H3,(H,27,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.25E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Materia Medica Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay in...				Eur J Med Chem 44: 1167-71 (2009) Article DOI: 10.1016/j.ejmech.2008.06.005 BindingDB Entry DOI: 10.7270/Q2251J0Z
					More data for this Ligand-Target Pair