BindingDB PrimarySearch

BDBM50249539 5-((1S,2R)-2-aminocyclohexylamino)-7-(3,5-dimethoxyphenylamino)-[1,2,4]triazolo[1,5-c]pyrimidine-8-carboxamide::5-((1S,2R)-2-aminocyclohexylamino)-7-(3,5-dimethoxyphenylamino)-[1,2,4]triazolo[1,5-f]pyrimidine-8-carboxamide::CHEMBL475575::cis-5-(2-Aminocyclohexylamino)-7-(3,5-dimethoxyphenylamino)-1,2,4-triazolo[1,5-c]pyrimidine-8-carboxamide

SMILES: COc1cc(Nc2nc(N[C@H]3CCCC[C@H]3N)n3ncnc3c2C(N)=O)cc(OC)c1

InChI Key: InChIKey=RVIMFNLCTIXVKN-CABCVRRESA-N

Data: 7 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50249539
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50249539 (5-((1S,2R)-2-aminocyclohexylamino)-7-(3,5-dimethox...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	590	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Company Ltd Curated by ChEMBL					Assay Description Inhibition of Lck (unknown origin)				Bioorg Med Chem 16: 7347-57 (2008) Article DOI: 10.1016/j.bmc.2008.06.017 BindingDB Entry DOI: 10.7270/Q2HQ3ZP6
Kissei Pharmaceutical Company Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
PKC alpha and beta-2 (Homo sapiens (Human))	BDBM50249539 (5-((1S,2R)-2-aminocyclohexylamino)-7-(3,5-dimethox...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.66E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Company Ltd Curated by ChEMBL					Assay Description Inhibition of PKCbeta2 (unknown origin)				Bioorg Med Chem 16: 7347-57 (2008) Article DOI: 10.1016/j.bmc.2008.06.017 BindingDB Entry DOI: 10.7270/Q2HQ3ZP6
Kissei Pharmaceutical Company Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM50249539 (5-((1S,2R)-2-aminocyclohexylamino)-7-(3,5-dimethox...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	330	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Company Ltd Curated by ChEMBL					Assay Description Inhibition of human ZAP70				Bioorg Med Chem 16: 7347-57 (2008) Article DOI: 10.1016/j.bmc.2008.06.017 BindingDB Entry DOI: 10.7270/Q2HQ3ZP6
Kissei Pharmaceutical Company Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM50249539 (5-((1S,2R)-2-aminocyclohexylamino)-7-(3,5-dimethox...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	330	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Company Ltd Curated by ChEMBL					Assay Description Inhibition of human ZAP70 expressed in Sf9 cells				Bioorg Med Chem 16: 9247-60 (2008) Article DOI: 10.1016/j.bmc.2008.09.015 BindingDB Entry DOI: 10.7270/Q2GM887N
Kissei Pharmaceutical Company Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50249539 (5-((1S,2R)-2-aminocyclohexylamino)-7-(3,5-dimethox...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of recombinant Syk (unknown origin)				Bioorg Med Chem Lett 19: 1944-9 (2009) Article DOI: 10.1016/j.bmcl.2009.02.049 BindingDB Entry DOI: 10.7270/Q2WM1D98
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50249539 (5-((1S,2R)-2-aminocyclohexylamino)-7-(3,5-dimethox...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Company Ltd Curated by ChEMBL					Assay Description Inhibition of human Syk expressed in Sf9 cells				Bioorg Med Chem 16: 9247-60 (2008) Article DOI: 10.1016/j.bmc.2008.09.015 BindingDB Entry DOI: 10.7270/Q2GM887N
Kissei Pharmaceutical Company Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Lysyl-tRNA synthetase (Homo sapiens (Human))	BDBM50249539 (5-((1S,2R)-2-aminocyclohexylamino)-7-(3,5-dimethox...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Company Ltd Curated by ChEMBL					Assay Description Inhibition of human Syk				Bioorg Med Chem 16: 7347-57 (2008) Article DOI: 10.1016/j.bmc.2008.06.017 BindingDB Entry DOI: 10.7270/Q2HQ3ZP6
Kissei Pharmaceutical Company Ltd Curated by ChEMBL					More data for this Ligand-Target Pair