BDBM50249645 CHEMBL4078859

SMILES: COc1ccc(Cn2ccc3nc(N)nc(NCc4cc(C)on4)c23)nc1OC

InChI Key: InChIKey=TZAKGYMSVWIROS-UHFFFAOYSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50249645   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50249645 (CHEMBL4078859) Show SMILES COc1ccc(Cn2ccc3nc(N)nc(NCc4cc(C)on4)c23)nc1OC Show InChI InChI=1S/C19H21N7O3/c1-11-8-13(25-29-11)9-21-17-16-14(23-19(20)24-17)6-7-26(16)10-12-4-5-15(27-2)18(22-12)28-3/h4-8H,9-10H2,1-3H3,(H3,20,21,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica , N. V. Turnhoutseweg 30, 2340 Beerse, Belgium. Curated by ChEMBL					Assay Description Displacement of 3H-dofetilide from human ERG				J Med Chem 60: 6137-6151 (2017) Article DOI: 10.1021/acs.jmedchem.7b00365 BindingDB Entry DOI: 10.7270/Q2XP77CC
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM50249645 (CHEMBL4078859) Show SMILES COc1ccc(Cn2ccc3nc(N)nc(NCc4cc(C)on4)c23)nc1OC Show InChI InChI=1S/C19H21N7O3/c1-11-8-13(25-29-11)9-21-17-16-14(23-19(20)24-17)6-7-26(16)10-12-4-5-15(27-2)18(22-12)28-3/h4-8H,9-10H2,1-3H3,(H3,20,21,23,24)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	0.600	n/a	n/a	n/a	n/a
Janssen Pharmaceutica , N. V. Turnhoutseweg 30, 2340 Beerse, Belgium. Curated by ChEMBL					Assay Description Agonist activity at TLR7 in human PBMC assessed as induction of IFNalpha-mediated inhibition of HCV genotype 1b RNA replication in human HuH luc/neo ...				J Med Chem 60: 6137-6151 (2017) Article DOI: 10.1021/acs.jmedchem.7b00365 BindingDB Entry DOI: 10.7270/Q2XP77CC
					More data for this Ligand-Target Pair