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BDBM50249836 CHEMBL4095086

SMILES: CCN1C(=O)S\C(=C/c2ccc(N3CCCC3)c(F)c2)C1=O

InChI Key: InChIKey=ABBSYEVTZRYOEH-UVTDQMKNSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50249836   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
GATA4/NKX2-5


(Mus musculus)		BDBM50249836
PNG
(CHEMBL4095086)
Show SMILES CCN1C(=O)S\C(=C/c2ccc(N3CCCC3)c(F)c2)C1=O
Show InChI InChI=1S/C16H17FN2O2S/c1-2-19-15(20)14(22-16(19)21)10-11-5-6-13(12(17)9-11)18-7-3-4-8-18/h5-6,9-10H,2-4,7-8H2,1H3/b14-10-
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 8.00E+3n/an/an/an/an/an/a



Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki , Helsinki FI-00014, Finland.

Curated by ChEMBL


Assay Description
Inhibition of mouse GATA4/NKX2-5 transcriptional synergy expressed in African green monkey COS-1 cells measured after 30 hrs by dual luciferase repor...

J Med Chem 60: 7781-7798 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00816
BindingDB Entry DOI: 10.7270/Q2DN47GK
More data for this
Ligand-Target Pair