BindingDB logo
myBDB logout

BDBM50249945 CHEMBL4081188

SMILES: CCOc1ccc(NC(=O)c2c(C)onc2-c2ccccc2)cc1

InChI Key: InChIKey=KVJPVXANYPKHKD-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50249945   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
GATA4/NKX2-5


(Mus musculus)		BDBM50249945
PNG
(CHEMBL4081188)
Show SMILES CCOc1ccc(NC(=O)c2c(C)onc2-c2ccccc2)cc1
Show InChI InChI=1S/C19H18N2O3/c1-3-23-16-11-9-15(10-12-16)20-19(22)17-13(2)24-21-18(17)14-7-5-4-6-8-14/h4-12H,3H2,1-2H3,(H,20,22)
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2.00E+4n/an/an/an/an/an/a



Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki , Helsinki FI-00014, Finland.

Curated by ChEMBL


Assay Description
Inhibition of mouse GATA4/NKX2-5 transcriptional synergy expressed in African green monkey COS-1 cells measured after 30 hrs by dual luciferase repor...

J Med Chem 60: 7781-7798 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00816
BindingDB Entry DOI: 10.7270/Q2DN47GK
More data for this
Ligand-Target Pair