BDBM50251053 CHEMBL4075032

SMILES: O=c1[nH]c(nc2sc3CN(Cc4ccccc4)CCc3c12)-c1ccccc1

InChI Key: InChIKey=XLDCJWXVCZUSKW-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50251053   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bromodomain-containing protein 4 (Homo sapiens (Human))	BDBM50251053 (CHEMBL4075032) Show SMILES O=c1[nH]c(nc2sc3CN(Cc4ccccc4)CCc3c12)-c1ccccc1 Show InChI InChI=1S/C22H19N3OS/c26-21-19-17-11-12-25(13-15-7-3-1-4-8-15)14-18(17)27-22(19)24-20(23-21)16-9-5-2-6-10-16/h1-10H,11-14H2,(H,23,24,26)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University and Collaborative Innovation Center of Biotherapy Curated by ChEMBL					Assay Description Inhibition of GST-tagged BRD4 bromodomain (unknown origin) using biotinylated histone H4KAc peptide (1 to 21 residues) as substrate by HTRF assay				J Med Chem 63: 3678-3700 (2020) Article DOI: 10.1021/acs.jmedchem.9b02178
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 (Homo sapiens (Human))	BDBM50251053 (CHEMBL4075032) Show SMILES O=c1[nH]c(nc2sc3CN(Cc4ccccc4)CCc3c12)-c1ccccc1 Show InChI InChI=1S/C22H19N3OS/c26-21-19-17-11-12-25(13-15-7-3-1-4-8-15)14-18(17)27-22(19)24-20(23-21)16-9-5-2-6-10-16/h1-10H,11-14H2,(H,23,24,26)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of His/thioredoxin-tagged human recombinant BRD4 bromodomain-1 (43 to 166 residues) expressed in Escherichia coli BL21 Star (DE3) pre-incu...				J Med Chem 60: 9990-10012 (2017) Article DOI: 10.1021/acs.jmedchem.7b00275 BindingDB Entry DOI: 10.7270/Q2M32Z68
					More data for this Ligand-Target Pair