BDBM50252018 (5-fluoro-2-(4-(methylthio)phenoxy)phenyl)-N,N-dimethylmethanamine::1-(5-fluoro-2-(4-(methylthio)phenoxy)phenyl)-N,N-dimethylmethanamine::CHEMBL446481
SMILES: CSc1ccc(Oc2ccc(F)cc2CN(C)C)cc1
InChI Key: InChIKey=FDNFLRXXOIWCQA-UHFFFAOYSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium-dependent dopamine transporter (Homo sapiens (Human)) | BDBM50252018 ((5-fluoro-2-(4-(methylthio)phenoxy)phenyl)-N,N-dim...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells | Bioorg Med Chem Lett 18: 4018-21 (2008) Article DOI: 10.1016/j.bmcl.2008.06.001 BindingDB Entry DOI: 10.7270/Q2W37W4X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM50252018 ((5-fluoro-2-(4-(methylthio)phenoxy)phenyl)-N,N-dim...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells | Bioorg Med Chem Lett 18: 5303-6 (2008) Article DOI: 10.1016/j.bmcl.2008.08.040 BindingDB Entry DOI: 10.7270/Q20K28DX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM50252018 ((5-fluoro-2-(4-(methylthio)phenoxy)phenyl)-N,N-dim...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells | Bioorg Med Chem Lett 18: 4018-21 (2008) Article DOI: 10.1016/j.bmcl.2008.06.001 BindingDB Entry DOI: 10.7270/Q2W37W4X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent noradrenaline transporter (Homo sapiens (Human)) | BDBM50252018 ((5-fluoro-2-(4-(methylthio)phenoxy)phenyl)-N,N-dim...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 630 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells | Bioorg Med Chem Lett 18: 4018-21 (2008) Article DOI: 10.1016/j.bmcl.2008.06.001 BindingDB Entry DOI: 10.7270/Q2W37W4X | |||||||||||
More data for this Ligand-Target Pair |