null

SMILES: C[C@H](N1CC[C@@](CCCO)(OC1=O)c1ccccc1)c1ccc(cc1)-c1cncc(F)c1

InChI Key: InChIKey=QAJYZVCUZHBDBT-AFMDSPMNSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50253514   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50253514 (CHEMBL4075869) Show SMILES C[C@H](N1CC[C@@](CCCO)(OC1=O)c1ccccc1)c1ccc(cc1)-c1cncc(F)c1 |r| Show InChI InChI=1S/C26H27FN2O3/c1-19(20-8-10-21(11-9-20)22-16-24(27)18-28-17-22)29-14-13-26(12-5-15-30,32-25(29)31)23-6-3-2-4-7-23/h2-4,6-11,16-19,30H,5,12-15H2,1H3/t19-,26+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry, Vitae Pharmaceuticals, Inc, 502 West Office Center Drive, Fort Washington, PA 19034, United States. Electronic address: linghang_zhuang@yahoo.com. Curated by ChEMBL					Assay Description Inhibition of 11beta-HSD1 in human omental adipocytes using [3H]cortisone as substrate preincubated for 1 hr followed by substrate addition measured ...				Bioorg Med Chem 25: 3649-3657 (2017) Article DOI: 10.1016/j.bmc.2017.04.033 BindingDB Entry DOI: 10.7270/Q2KS6V0F
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50253514 (CHEMBL4075869) Show SMILES C[C@H](N1CC[C@@](CCCO)(OC1=O)c1ccccc1)c1ccc(cc1)-c1cncc(F)c1 |r| Show InChI InChI=1S/C26H27FN2O3/c1-19(20-8-10-21(11-9-20)22-16-24(27)18-28-17-22)29-14-13-26(12-5-15-30,32-25(29)31)23-6-3-2-4-7-23/h2-4,6-11,16-19,30H,5,12-15H2,1H3/t19-,26+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry, Vitae Pharmaceuticals, Inc, 502 West Office Center Drive, Fort Washington, PA 19034, United States. Electronic address: linghang_zhuang@yahoo.com. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 expressed in CHO cell microsomes using [3H]cortisone as substrate preincubated with substrate for 10 mins followed by...				Bioorg Med Chem 25: 3649-3657 (2017) Article DOI: 10.1016/j.bmc.2017.04.033 BindingDB Entry DOI: 10.7270/Q2KS6V0F
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50253514 (CHEMBL4075869) Show SMILES C[C@H](N1CC[C@@](CCCO)(OC1=O)c1ccccc1)c1ccc(cc1)-c1cncc(F)c1 |r| Show InChI InChI=1S/C26H27FN2O3/c1-19(20-8-10-21(11-9-20)22-16-24(27)18-28-17-22)29-14-13-26(12-5-15-30,32-25(29)31)23-6-3-2-4-7-23/h2-4,6-11,16-19,30H,5,12-15H2,1H3/t19-,26+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry, Vitae Pharmaceuticals, Inc, 502 West Office Center Drive, Fort Washington, PA 19034, United States. Electronic address: linghang_zhuang@yahoo.com. Curated by ChEMBL					Assay Description Inhibition of recombinant CYP3A4 (unknown origin)				Bioorg Med Chem 25: 3649-3657 (2017) Article DOI: 10.1016/j.bmc.2017.04.033 BindingDB Entry DOI: 10.7270/Q2KS6V0F
					More data for this Ligand-Target Pair