BDBM50254857 (R)-N-(2,5-dioxo-1',3'-dihydrospiro[imidazolidine-4,2'-indene]-5'-yl)-2-(2-oxo-3-(pyridin-2-yl)-2,3-dihydro-1H-benzo[d]imidazol-1-yl)acetamide::CHEMBL465279
SMILES: O=C(Cn1c2ccccc2n(-c2ccccn2)c1=O)Nc1ccc2C[C@]3(Cc2c1)NC(=O)NC3=O
InChI Key: InChIKey=YQFDHOVFVOTRLH-RUZDIDTESA-N
Data: 1 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Calcitonin gene-related peptide type 1 receptor (Homo sapiens (Human)) | BDBM50254857![]() ((R)-N-(2,5-dioxo-1',3'-dihydrospiro[imidazolidine-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 230 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck& Co Curated by ChEMBL | Assay Description Displacement of [125I]hCGRP from human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 | Bioorg Med Chem Lett 19: 214-7 (2008) Article DOI: 10.1016/j.bmcl.2008.10.106 BindingDB Entry DOI: 10.7270/Q21C1XSK | |||||||||||
More data for this Ligand-Target Pair |