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BDBM50256097 CHEMBL4083557

SMILES: COc1cc(Nc2cc(nc3CCNC(=O)c23)-c2ccccc2)cc(OC)c1

InChI Key: InChIKey=WVMCWUYAWKSAEP-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50256097   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50256097
PNG
(CHEMBL4083557)
Show SMILES COc1cc(Nc2cc(nc3CCNC(=O)c23)-c2ccccc2)cc(OC)c1
Show InChI InChI=1S/C22H21N3O3/c1-27-16-10-15(11-17(12-16)28-2)24-20-13-19(14-6-4-3-5-7-14)25-18-8-9-23-22(26)21(18)20/h3-7,10-13H,8-9H2,1-2H3,(H,23,26)(H,24,25)
PDB

UniProtKB/SwissProt

antibodypedia
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PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 27n/an/an/an/an/an/a



Medicinal Chemistry& Screening ,?Pharmacokinetics& Metabolism , and§Experimental Dermatology , Almirall S.A., Centro de Investigación y Desarrollo , Crta. Laureà Miró 408-410 , Sant Feliu de

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE4B1 using [3H]-cAMP as substrate preincubated for 15 mins followed substrate addition measured after 60 mins by sc...

J Med Chem 61: 2472-2489 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01751
BindingDB Entry DOI: 10.7270/Q2HQ42BB
More data for this
Ligand-Target Pair