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SMILES: NC(=O)c1cccc(Nc2cc(nc3CCNC(=O)c23)-c2ccccc2)c1

InChI Key: InChIKey=LIVXRAZDMGHLSN-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50256101   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50256101
PNG
(CHEMBL4090819)
Show SMILES NC(=O)c1cccc(Nc2cc(nc3CCNC(=O)c23)-c2ccccc2)c1
Show InChI InChI=1S/C21H18N4O2/c22-20(26)14-7-4-8-15(11-14)24-18-12-17(13-5-2-1-3-6-13)25-16-9-10-23-21(27)19(16)18/h1-8,11-12H,9-10H2,(H2,22,26)(H,23,27)(H,24,25)
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Article
PubMed
n/an/a 12n/an/an/an/an/an/a



Medicinal Chemistry& Screening ,?Pharmacokinetics& Metabolism , and§Experimental Dermatology , Almirall S.A., Centro de Investigación y Desarrollo , Crta. Laureà Miró 408-410 , Sant Feliu de

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE4B1 using [3H]-cAMP as substrate preincubated for 15 mins followed substrate addition measured after 60 mins by sc...

J Med Chem 61: 2472-2489 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01751
BindingDB Entry DOI: 10.7270/Q2HQ42BB
More data for this
Ligand-Target Pair