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SMILES: O=C1NCCc2nc(cc(Nc3cccc4ncccc34)c12)-c1ccccc1

InChI Key: InChIKey=KZRSALSNMARGNI-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50256133   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50256133
PNG
(CHEMBL4064980)
Show SMILES O=C1NCCc2nc(cc(Nc3cccc4ncccc34)c12)-c1ccccc1
Show InChI InChI=1S/C23H18N4O/c28-23-22-19(11-13-25-23)27-20(15-6-2-1-3-7-15)14-21(22)26-18-10-4-9-17-16(18)8-5-12-24-17/h1-10,12,14H,11,13H2,(H,25,28)(H,26,27)
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Article
PubMed
n/an/a 0.960n/an/an/an/an/an/a



Medicinal Chemistry& Screening ,?Pharmacokinetics& Metabolism , and§Experimental Dermatology , Almirall S.A., Centro de Investigación y Desarrollo , Crta. Laureà Miró 408-410 , Sant Feliu de

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE4B1 using [3H]-cAMP as substrate preincubated for 15 mins followed substrate addition measured after 60 mins by sc...

J Med Chem 61: 2472-2489 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01751
BindingDB Entry DOI: 10.7270/Q2HQ42BB
More data for this
Ligand-Target Pair