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SMILES: Cn1nc(Nc2cc(nc3CCNC(=O)c23)-c2ccccc2)c2cccnc12

InChI Key: InChIKey=CHSNTVSQTLMNEZ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50256136   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50256136
PNG
(CHEMBL4083943)
Show SMILES Cn1nc(Nc2cc(nc3CCNC(=O)c23)-c2ccccc2)c2cccnc12
Show InChI InChI=1S/C21H18N6O/c1-27-20-14(8-5-10-22-20)19(26-27)25-17-12-16(13-6-3-2-4-7-13)24-15-9-11-23-21(28)18(15)17/h2-8,10,12H,9,11H2,1H3,(H,23,28)(H,24,25,26)
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Article
PubMed
n/an/a 11n/an/an/an/an/an/a



Medicinal Chemistry& Screening ,?Pharmacokinetics& Metabolism , and§Experimental Dermatology , Almirall S.A., Centro de Investigación y Desarrollo , Crta. Laureà Miró 408-410 , Sant Feliu de

Curated by ChEMBL


Assay Description
Inhibition of platelet derived growth factor receptor beta phosphorylation in MG63 cells in the presence of human plasma

J Med Chem 61: 2472-2489 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01751
BindingDB Entry DOI: 10.7270/Q2HQ42BB
More data for this
Ligand-Target Pair