BDBM50256144 CHEMBL4103569

SMILES: Fc1ccc(cc1F)-c1cc(Nc2cccc3ncccc23)c2C(=O)NCCc2n1

InChI Key: InChIKey=JJEPFUGVOBPADY-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50256144   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50256144 (CHEMBL4103569) Show SMILES Fc1ccc(cc1F)-c1cc(Nc2cccc3ncccc23)c2C(=O)NCCc2n1 Show InChI InChI=1S/C23H16F2N4O/c24-15-7-6-13(11-16(15)25)20-12-21(22-19(29-20)8-10-27-23(22)30)28-18-5-1-4-17-14(18)3-2-9-26-17/h1-7,9,11-12H,8,10H2,(H,27,30)(H,28,29)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.75	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry& Screening ,?Pharmacokinetics& Metabolism , and§Experimental Dermatology , Almirall S.A., Centro de Investigación y Desarrollo , Crta. Laureà Miró 408-410 , Sant Feliu de Curated by ChEMBL					Assay Description Inhibition of platelet derived growth factor receptor beta phosphorylation in MG63 cells in the presence of human plasma				J Med Chem 61: 2472-2489 (2018) Article DOI: 10.1021/acs.jmedchem.7b01751 BindingDB Entry DOI: 10.7270/Q2HQ42BB
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