BDBM50256152 CHEMBL4076176

SMILES: Oc1cccc(c1)-c1cccc(c1)-c1cc(Nc2cccc3ncccc23)c2C(=O)NCCc2n1

InChI Key: InChIKey=BUWUSUNGGWBCBV-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50256152   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50256152 (CHEMBL4076176) Show SMILES Oc1cccc(c1)-c1cccc(c1)-c1cc(Nc2cccc3ncccc23)c2C(=O)NCCc2n1 Show InChI InChI=1S/C29H22N4O2/c34-21-8-2-6-19(16-21)18-5-1-7-20(15-18)26-17-27(28-25(33-26)12-14-31-29(28)35)32-24-11-3-10-23-22(24)9-4-13-30-23/h1-11,13,15-17,34H,12,14H2,(H,31,35)(H,32,33)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.890	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry& Screening ,?Pharmacokinetics& Metabolism , and§Experimental Dermatology , Almirall S.A., Centro de Investigación y Desarrollo , Crta. Laureà Miró 408-410 , Sant Feliu de Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE4B1 using [3H]-cAMP as substrate preincubated for 15 mins followed substrate addition measured after 60 mins by sc...				J Med Chem 61: 2472-2489 (2018) Article DOI: 10.1021/acs.jmedchem.7b01751 BindingDB Entry DOI: 10.7270/Q2HQ42BB
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