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SMILES: O=C(NC1CC1)c1cccc(c1)-c1cccc(c1)-c1cc(Nc2cncc3ccccc23)c2C(=O)NCCc2n1

InChI Key: InChIKey=NZPBQMMLBCTDKI-UHFFFAOYSA-N

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50256155   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50256155
PNG
(CHEMBL4087620)
Show SMILES O=C(NC1CC1)c1cccc(c1)-c1cccc(c1)-c1cc(Nc2cncc3ccccc23)c2C(=O)NCCc2n1
Show InChI InChI=1S/C33H27N5O2/c39-32(36-25-11-12-25)23-9-4-7-21(16-23)20-6-3-8-22(15-20)28-17-29(31-27(37-28)13-14-35-33(31)40)38-30-19-34-18-24-5-1-2-10-26(24)30/h1-10,15-19,25H,11-14H2,(H,35,40)(H,36,39)(H,37,38)
PDB

UniProtKB/SwissProt

antibodypedia
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AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.320n/an/an/an/an/an/a



Medicinal Chemistry& Screening ,?Pharmacokinetics& Metabolism , and§Experimental Dermatology , Almirall S.A., Centro de Investigación y Desarrollo , Crta. Laureà Miró 408-410 , Sant Feliu de

Curated by ChEMBL


Assay Description
Inhibition of platelet derived growth factor receptor beta phosphorylation in MG63 cells in the presence of human plasma

J Med Chem 61: 2472-2489 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01751
BindingDB Entry DOI: 10.7270/Q2HQ42BB
More data for this
Ligand-Target Pair