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BDBM50256193 CHEMBL4087186

SMILES: Fc1ccc(cc1F)-c1cc(Nc2cccc3ncccc23)c2\C(NCCc2n1)=N\C#N

InChI Key: InChIKey=IYUZAUFNGUWGDQ-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50256193   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50256193
PNG
(CHEMBL4087186)
Show SMILES Fc1ccc(cc1F)-c1cc(Nc2cccc3ncccc23)c2\C(NCCc2n1)=N\C#N
Show InChI InChI=1S/C24H16F2N6/c25-16-7-6-14(11-17(16)26)21-12-22(23-20(32-21)8-10-29-24(23)30-13-27)31-19-5-1-4-18-15(19)3-2-9-28-18/h1-7,9,11-12H,8,10H2,(H,29,30)(H,31,32)
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
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PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 0.890n/an/an/an/an/an/a



Medicinal Chemistry& Screening ,?Pharmacokinetics& Metabolism , and§Experimental Dermatology , Almirall S.A., Centro de Investigación y Desarrollo , Crta. Laureà Miró 408-410 , Sant Feliu de

Curated by ChEMBL


Assay Description
Inhibition of platelet derived growth factor receptor beta phosphorylation in MG63 cells in the presence of human plasma

J Med Chem 61: 2472-2489 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01751
BindingDB Entry DOI: 10.7270/Q2HQ42BB
More data for this
Ligand-Target Pair