BDBM50256194 CHEMBL4066266

SMILES: O=C(NC1CC1)c1cccc(c1)-c1cccc(c1)-c1cc(Nc2ccnc3ccccc23)c2C(=O)NCCc2n1

InChI Key: InChIKey=HNEJJHGMWCDPAP-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50256194   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50256194 (CHEMBL4066266) Show SMILES O=C(NC1CC1)c1cccc(c1)-c1cccc(c1)-c1cc(Nc2ccnc3ccccc23)c2C(=O)NCCc2n1 Show InChI InChI=1S/C33H27N5O2/c39-32(36-24-11-12-24)23-8-4-6-21(18-23)20-5-3-7-22(17-20)29-19-30(31-28(38-29)14-16-35-33(31)40)37-27-13-15-34-26-10-2-1-9-25(26)27/h1-10,13,15,17-19,24H,11-12,14,16H2,(H,35,40)(H,36,39)(H,34,37,38)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.270	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry& Screening ,?Pharmacokinetics& Metabolism , and§Experimental Dermatology , Almirall S.A., Centro de Investigación y Desarrollo , Crta. Laureà Miró 408-410 , Sant Feliu de Curated by ChEMBL					Assay Description Inhibition of platelet-derived growth factor receptor beta phosphorylation in MG63 cells in the absence of plasma				J Med Chem 61: 2472-2489 (2018) Article DOI: 10.1021/acs.jmedchem.7b01751 BindingDB Entry DOI: 10.7270/Q2HQ42BB
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