BDBM50256745 (2S)-2-amino-3-((2-(benzyloxy)phenyl)(3-fluorophenyl)methoxy)propanoic acid::CHEMBL475562

SMILES: N[C@@H](COC(c1cccc(F)c1)c1ccccc1OCc1ccccc1)C(O)=O

InChI Key: InChIKey=ADUSZEGHFWRTQS-AIBWNMTMSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50256745   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Galanin receptor 2 (RAT)	BDBM50256745 ((2S)-2-amino-3-((2-(benzyloxy)phenyl)(3-fluorophen...) Show SMILES N[C@@H](COC(c1cccc(F)c1)c1ccccc1OCc1ccccc1)C(O)=O |r| Show InChI InChI=1S/C23H22FNO4/c24-18-10-6-9-17(13-18)22(29-15-20(25)23(26)27)19-11-4-5-12-21(19)28-14-16-7-2-1-3-8-16/h1-13,20,22H,14-15,25H2,(H,26,27)/t20-,22?/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	21.1	n/a	n/a	n/a	n/a	n/a	n/a
Taisho Pharmaceutical Co., Ltd Curated by ChEMBL					Assay Description Inhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cells				Bioorg Med Chem Lett 18: 6321-3 (2008) Article DOI: 10.1016/j.bmcl.2008.10.104 BindingDB Entry DOI: 10.7270/Q2BZ65WC
					More data for this Ligand-Target Pair
Glycine transporter 2 (Homo sapiens (Human))	BDBM50256745 ((2S)-2-amino-3-((2-(benzyloxy)phenyl)(3-fluorophen...) Show SMILES N[C@@H](COC(c1cccc(F)c1)c1ccccc1OCc1ccccc1)C(O)=O |r| Show InChI InChI=1S/C23H22FNO4/c24-18-10-6-9-17(13-18)22(29-15-20(25)23(26)27)19-11-4-5-12-21(19)28-14-16-7-2-1-3-8-16/h1-13,20,22H,14-15,25H2,(H,26,27)/t20-,22?/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Albany College of Pharmacy and Health Sciences Curated by ChEMBL					Assay Description Inhibition of human GlyT-2 expressed in HEK293 cells assessed as reduction in [3H]-glycine uptake preincubated for 30 mins followed by 3H]-glycine ad...				J Med Chem 61: 2652-2679 (2018) Article DOI: 10.1021/acs.jmedchem.7b00956 BindingDB Entry DOI: 10.7270/Q23B62RZ
					More data for this Ligand-Target Pair
Glycine transporter 2 (Homo sapiens (Human))	BDBM50256745 ((2S)-2-amino-3-((2-(benzyloxy)phenyl)(3-fluorophen...) Show SMILES N[C@@H](COC(c1cccc(F)c1)c1ccccc1OCc1ccccc1)C(O)=O |r| Show InChI InChI=1S/C23H22FNO4/c24-18-10-6-9-17(13-18)22(29-15-20(25)23(26)27)19-11-4-5-12-21(19)28-14-16-7-2-1-3-8-16/h1-13,20,22H,14-15,25H2,(H,26,27)/t20-,22?/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas at El Paso Curated by ChEMBL					Assay Description Inhibition of human GlyT2 expressed in porcine aorta epithelial cells assessed as reduction in [3H]-Glycine uptake at pH 7.5 by scintillation spectro...				ACS Med Chem Lett 10: 904-910 (2019) Article DOI: 10.1021/acsmedchemlett.9b00003
					More data for this Ligand-Target Pair
Glycine transporter 2 (Homo sapiens (Human))	BDBM50256745 ((2S)-2-amino-3-((2-(benzyloxy)phenyl)(3-fluorophen...) Show SMILES N[C@@H](COC(c1cccc(F)c1)c1ccccc1OCc1ccccc1)C(O)=O |r| Show InChI InChI=1S/C23H22FNO4/c24-18-10-6-9-17(13-18)22(29-15-20(25)23(26)27)19-11-4-5-12-21(19)28-14-16-7-2-1-3-8-16/h1-13,20,22H,14-15,25H2,(H,26,27)/t20-,22?/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Inhibition of full length human GlyT2 expressed in FreeStyle 293-F suspension cells incubated for 30 mins before [3H]glycine addition and measured af...				J Med Chem 62: 2466-2484 (2019) Article DOI: 10.1021/acs.jmedchem.8b01775
					More data for this Ligand-Target Pair
Glycine transporter 1 (Homo sapiens (Human))	BDBM50256745 ((2S)-2-amino-3-((2-(benzyloxy)phenyl)(3-fluorophen...) Show SMILES N[C@@H](COC(c1cccc(F)c1)c1ccccc1OCc1ccccc1)C(O)=O |r| Show InChI InChI=1S/C23H22FNO4/c24-18-10-6-9-17(13-18)22(29-15-20(25)23(26)27)19-11-4-5-12-21(19)28-14-16-7-2-1-3-8-16/h1-13,20,22H,14-15,25H2,(H,26,27)/t20-,22?/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Albany College of Pharmacy and Health Sciences Curated by ChEMBL					Assay Description Inhibition of human GlyT-1 expressed in HEK293 cells assessed as reduction in [3H]-glycine uptake preincubated for 30 mins followed by 3H]-glycine ad...				J Med Chem 61: 2652-2679 (2018) Article DOI: 10.1021/acs.jmedchem.7b00956 BindingDB Entry DOI: 10.7270/Q23B62RZ
					More data for this Ligand-Target Pair