BDBM50257550 CHEMBL4075762

SMILES: O[C@H]1CC[C@@H](CC1)Nc1ccc(cc1Cl)-c1ccn2c(CC(F)(F)F)nnc2c1Cl

InChI Key: InChIKey=CKPDPPZRMSOYJQ-JOCQHMNTSA-N

Data: 1 KI  1 Kd  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50257550   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50257550 (CHEMBL4075762) Show SMILES O[C@H]1CC[C@@H](CC1)Nc1ccc(cc1Cl)-c1ccn2c(CC(F)(F)F)nnc2c1Cl |r,wU:4.7,wD:1.0,(51.9,-27.77,;51.91,-26.23,;53.25,-25.46,;53.26,-23.92,;51.92,-23.16,;50.58,-23.92,;50.58,-25.45,;51.92,-21.62,;53.26,-20.85,;54.59,-21.62,;55.93,-20.85,;55.92,-19.3,;54.59,-18.53,;53.26,-19.3,;51.93,-18.53,;57.25,-18.52,;58.59,-19.29,;59.91,-18.52,;59.91,-16.98,;61.05,-15.94,;62.56,-16.26,;63.04,-17.72,;62.02,-18.87,;64.55,-18.03,;63.44,-19.2,;60.42,-14.54,;58.89,-14.71,;58.58,-16.21,;57.24,-16.99,;55.91,-16.22,)| Show InChI InChI=1S/C20H19Cl2F3N4O/c21-15-9-11(1-6-16(15)26-12-2-4-13(30)5-3-12)14-7-8-29-17(10-20(23,24)25)27-28-19(29)18(14)22/h1,6-9,12-13,26,30H,2-5,10H2/t12-,13-	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research (LACDR), Leiden University , P.O. Box 9502, 2300RA Leiden, The Netherlands. Curated by ChEMBL					Assay Description Displacement of [3H]-JNJ46281222 from human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes after 60 mins by microbeta counting a...				J Med Chem 60: 6704-6720 (2017) Article DOI: 10.1021/acs.jmedchem.7b00669 BindingDB Entry DOI: 10.7270/Q24B33RJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50257550 (CHEMBL4075762) Show SMILES O[C@H]1CC[C@@H](CC1)Nc1ccc(cc1Cl)-c1ccn2c(CC(F)(F)F)nnc2c1Cl |r,wU:4.7,wD:1.0,(51.9,-27.77,;51.91,-26.23,;53.25,-25.46,;53.26,-23.92,;51.92,-23.16,;50.58,-23.92,;50.58,-25.45,;51.92,-21.62,;53.26,-20.85,;54.59,-21.62,;55.93,-20.85,;55.92,-19.3,;54.59,-18.53,;53.26,-19.3,;51.93,-18.53,;57.25,-18.52,;58.59,-19.29,;59.91,-18.52,;59.91,-16.98,;61.05,-15.94,;62.56,-16.26,;63.04,-17.72,;62.02,-18.87,;64.55,-18.03,;63.44,-19.2,;60.42,-14.54,;58.89,-14.71,;58.58,-16.21,;57.24,-16.99,;55.91,-16.22,)| Show InChI InChI=1S/C20H19Cl2F3N4O/c21-15-9-11(1-6-16(15)26-12-2-4-13(30)5-3-12)14-7-8-29-17(10-20(23,24)25)27-28-19(29)18(14)22/h1,6-9,12-13,26,30H,2-5,10H2/t12-,13-	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a
Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research (LACDR), Leiden University , P.O. Box 9502, 2300RA Leiden, The Netherlands. Curated by ChEMBL					Assay Description Binding affinity to human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes by scintillation proximity assay				J Med Chem 60: 6704-6720 (2017) Article DOI: 10.1021/acs.jmedchem.7b00669 BindingDB Entry DOI: 10.7270/Q24B33RJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50257550 (CHEMBL4075762) Show SMILES O[C@H]1CC[C@@H](CC1)Nc1ccc(cc1Cl)-c1ccn2c(CC(F)(F)F)nnc2c1Cl |r,wU:4.7,wD:1.0,(51.9,-27.77,;51.91,-26.23,;53.25,-25.46,;53.26,-23.92,;51.92,-23.16,;50.58,-23.92,;50.58,-25.45,;51.92,-21.62,;53.26,-20.85,;54.59,-21.62,;55.93,-20.85,;55.92,-19.3,;54.59,-18.53,;53.26,-19.3,;51.93,-18.53,;57.25,-18.52,;58.59,-19.29,;59.91,-18.52,;59.91,-16.98,;61.05,-15.94,;62.56,-16.26,;63.04,-17.72,;62.02,-18.87,;64.55,-18.03,;63.44,-19.2,;60.42,-14.54,;58.89,-14.71,;58.58,-16.21,;57.24,-16.99,;55.91,-16.22,)| Show InChI InChI=1S/C20H19Cl2F3N4O/c21-15-9-11(1-6-16(15)26-12-2-4-13(30)5-3-12)14-7-8-29-17(10-20(23,24)25)27-28-19(29)18(14)22/h1,6-9,12-13,26,30H,2-5,10H2/t12-,13-	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	42	n/a	n/a	n/a	n/a
Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research (LACDR), Leiden University , P.O. Box 9502, 2300RA Leiden, The Netherlands. Curated by ChEMBL					Assay Description Displacement of [3H]-JNJ46281222 from human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes after 60 mins by liquid scintillation...				J Med Chem 60: 6704-6720 (2017) Article DOI: 10.1021/acs.jmedchem.7b00669 BindingDB Entry DOI: 10.7270/Q24B33RJ
					More data for this Ligand-Target Pair