BDBM50257596 CHEMBL4060306

SMILES: Clc1cc(ccc1NC1CC1)-c1ccn2c(CC3CC3)nnc2c1Cl

InChI Key: InChIKey=IIWHPWPVODSNOY-UHFFFAOYSA-N

Data: 1 KI  1 Kd  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50257596   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50257596 (CHEMBL4060306) Show SMILES Clc1cc(ccc1NC1CC1)-c1ccn2c(CC3CC3)nnc2c1Cl Show InChI InChI=1S/C19H18Cl2N4/c20-15-10-12(3-6-16(15)22-13-4-5-13)14-7-8-25-17(9-11-1-2-11)23-24-19(25)18(14)21/h3,6-8,10-11,13,22H,1-2,4-5,9H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	6.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research (LACDR), Leiden University , P.O. Box 9502, 2300RA Leiden, The Netherlands. Curated by ChEMBL					Assay Description Displacement of [3H]-JNJ46281222 from human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes after 60 mins by microbeta counting a...				J Med Chem 60: 6704-6720 (2017) Article DOI: 10.1021/acs.jmedchem.7b00669 BindingDB Entry DOI: 10.7270/Q24B33RJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50257596 (CHEMBL4060306) Show SMILES Clc1cc(ccc1NC1CC1)-c1ccn2c(CC3CC3)nnc2c1Cl Show InChI InChI=1S/C19H18Cl2N4/c20-15-10-12(3-6-16(15)22-13-4-5-13)14-7-8-25-17(9-11-1-2-11)23-24-19(25)18(14)21/h3,6-8,10-11,13,22H,1-2,4-5,9H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	6.10	n/a	n/a	n/a	n/a	n/a
Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research (LACDR), Leiden University , P.O. Box 9502, 2300RA Leiden, The Netherlands. Curated by ChEMBL					Assay Description Binding affinity to human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes by scintillation proximity assay				J Med Chem 60: 6704-6720 (2017) Article DOI: 10.1021/acs.jmedchem.7b00669 BindingDB Entry DOI: 10.7270/Q24B33RJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50257596 (CHEMBL4060306) Show SMILES Clc1cc(ccc1NC1CC1)-c1ccn2c(CC3CC3)nnc2c1Cl Show InChI InChI=1S/C19H18Cl2N4/c20-15-10-12(3-6-16(15)22-13-4-5-13)14-7-8-25-17(9-11-1-2-11)23-24-19(25)18(14)21/h3,6-8,10-11,13,22H,1-2,4-5,9H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	30	n/a	n/a	n/a	n/a
Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research (LACDR), Leiden University , P.O. Box 9502, 2300RA Leiden, The Netherlands. Curated by ChEMBL					Assay Description Positive allosteric modulation of human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes assessed as increase in glutamate-induced...				J Med Chem 60: 6704-6720 (2017) Article DOI: 10.1021/acs.jmedchem.7b00669 BindingDB Entry DOI: 10.7270/Q24B33RJ
					More data for this Ligand-Target Pair