BDBM50258036 CHEMBL494007::N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)-3-phenylpropiolamide::cid_44573597
SMILES: O=C(NCCN1CCC(CC1)n1c2ccccc2[nH]c1=O)C#Cc1ccccc1
InChI Key: InChIKey=ZCPAKJKFPGVKMN-UHFFFAOYSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phospholipase D2 (PLD2) (Homo sapiens (Human)) | BDBM50258036 (CHEMBL494007 | N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PCBioAssay | n/a | n/a | 730 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt Specialized Chemistry Center Curated by PubChem BioAssay | Assay Description Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i... | PubChem Bioassay (2011) BindingDB Entry DOI: 10.7270/Q21R6P4V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phospholipase D2 (PLD2) (Homo sapiens (Human)) | BDBM50258036 (CHEMBL494007 | N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 730 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Inhibition of GFP-labelled human PLD2 HEK293 cells | Bioorg Med Chem Lett 19: 1916-20 (2009) Article DOI: 10.1016/j.bmcl.2009.02.057 BindingDB Entry DOI: 10.7270/Q2VM4C5W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phospholipase D (PLD) (Homo sapiens (Human)) | BDBM50258036 (CHEMBL494007 | N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Inhibition of human PLD1 in Calu1 cells | Bioorg Med Chem Lett 19: 1916-20 (2009) Article DOI: 10.1016/j.bmcl.2009.02.057 BindingDB Entry DOI: 10.7270/Q2VM4C5W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phospholipase D (PLD) (Homo sapiens (Human)) | BDBM50258036 (CHEMBL494007 | N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PCBioAssay | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt Specialized Chemistry Center Curated by PubChem BioAssay | Assay Description Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i... | PubChem Bioassay (2011) BindingDB Entry DOI: 10.7270/Q2NK3CNK | |||||||||||
More data for this Ligand-Target Pair |