BDBM50258346 4-(4-methyl-1H-indol-5-ylamino)-5-(4-(2-(4-(pyrrolidin-1-yl)piperidin-1-yl)ethoxy)phenyl)nicotinonitrile::CHEMBL493999
SMILES: Cc1c(Nc2c(cncc2-c2ccc(OCCN3CCC(CC3)N3CCCC3)cc2)C#N)ccc2[nH]ccc12
InChI Key: InChIKey=FLWBAZOREVFEAD-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 50258346 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Protein kinase C delta type
(Homo sapiens (Human)) | BDBM50258346
(4-(4-methyl-1H-indol-5-ylamino)-5-(4-(2-(4-(pyrrol...)Show SMILES Cc1c(Nc2c(cncc2-c2ccc(OCCN3CCC(CC3)N3CCCC3)cc2)C#N)ccc2[nH]ccc12 Show InChI InChI=1S/C32H36N6O/c1-23-28-10-13-35-31(28)9-8-30(23)36-32-25(20-33)21-34-22-29(32)24-4-6-27(7-5-24)39-19-18-37-16-11-26(12-17-37)38-14-2-3-15-38/h4-10,13,21-22,26,35H,2-3,11-12,14-19H2,1H3,(H,34,36) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of human PKCdelta by IMAP assay |
Bioorg Med Chem Lett 19: 3623-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.126 BindingDB Entry DOI: 10.7270/Q29W0FD4 |
More data for this Ligand-Target Pair | |
Protein kinase C theta type
(Homo sapiens (Human)) | BDBM50258346
(4-(4-methyl-1H-indol-5-ylamino)-5-(4-(2-(4-(pyrrol...)Show SMILES Cc1c(Nc2c(cncc2-c2ccc(OCCN3CCC(CC3)N3CCCC3)cc2)C#N)ccc2[nH]ccc12 Show InChI InChI=1S/C32H36N6O/c1-23-28-10-13-35-31(28)9-8-30(23)36-32-25(20-33)21-34-22-29(32)24-4-6-27(7-5-24)39-19-18-37-16-11-26(12-17-37)38-14-2-3-15-38/h4-10,13,21-22,26,35H,2-3,11-12,14-19H2,1H3,(H,34,36) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of human PKCtheta by IMAP assay |
Bioorg Med Chem Lett 19: 3623-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.126 BindingDB Entry DOI: 10.7270/Q29W0FD4 |
More data for this Ligand-Target Pair | |