BDBM50258847 4-(1-(4-methoxyphenyl)cyclopentyl)thiazol-2-amine::CHEMBL449357

SMILES: COc1ccc(cc1)C1(CCCC1)c1csc(N)n1

InChI Key: InChIKey=CKMNYFMEILPBLI-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50258847   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Beta-secretase 1 (Homo sapiens (Human))	BDBM50258847 (4-(1-(4-methoxyphenyl)cyclopentyl)thiazol-2-amine ...) Show SMILES COc1ccc(cc1)C1(CCCC1)c1csc(N)n1 Show InChI InChI=1S/C15H18N2OS/c1-18-12-6-4-11(5-7-12)15(8-2-3-9-15)13-10-19-14(16)17-13/h4-7,10H,2-3,8-9H2,1H3,(H2,16,17)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	4.5	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of BACE1 (unknown origin) at pH 4.5				Bioorg Med Chem Lett 19: 2977-80 (2009) Article DOI: 10.1016/j.bmcl.2009.04.033 BindingDB Entry DOI: 10.7270/Q2XS5V96
					More data for this Ligand-Target Pair