BDBM50259956 2,6-Bis-hydroxymethyl-piperidine-3,4,5-triol::CHEMBL501355::US9181184, 34::alpha-homonojirimycin
SMILES: OC[C@H]1N[C@H](CO)[C@H](O)[C@@H](O)[C@@H]1O
InChI Key: InChIKey=CLVUFWXGNIFGNC-OVHBTUCOSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
alpha-glucosidase (Gaa) (Mus musculus (Mouse)) | BDBM50259956 (2,6-Bis-hydroxymethyl-piperidine-3,4,5-triol | CHE...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | n/a | n/a | 2.81E+5 | n/a | n/a | 4.0 | n/a |
Amicus Therapeutics, Inc. US Patent | Assay Description Cells were washed two times with 200 μL dPBS followed by the addition of 70 μL of substrate (2.11 mM 3 mM 4-MU-α-D-glu) in citrate-pho... | US Patent US9181184 (2015) BindingDB Entry DOI: 10.7270/Q2T43RWB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutral alpha-glucosidase C (Mus musculus) | BDBM50259956 (2,6-Bis-hydroxymethyl-piperidine-3,4,5-triol | CHE...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Chimie Organique et Analytique (I.C.O.A.) Curated by ChEMBL | Assay Description Inhibitory activity against alpha-glucosidase from rat intestinal maltase | Bioorg Med Chem Lett 9: 3171-4 (1999) BindingDB Entry DOI: 10.7270/Q2GT5MDZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acidic alpha-glucosidase (Rattus norvegicus) | BDBM50259956 (2,6-Bis-hydroxymethyl-piperidine-3,4,5-triol | CHE...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University Curated by ChEMBL | Assay Description Inhibitory activity measured against alpha-glucosidase of rat intestinal sucrase by colorimetric assay using the D-glucose oxidase-peroxidase method | J Med Chem 41: 2565-71 (1998) Article DOI: 10.1021/jm970836l BindingDB Entry DOI: 10.7270/Q25D8SHK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acidic alpha-glucosidase (Rattus norvegicus) | BDBM50259956 (2,6-Bis-hydroxymethyl-piperidine-3,4,5-triol | CHE...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 8.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University Curated by ChEMBL | Assay Description Inhibitory activity measured against alpha-glucosidase of rat liver ER glucosidase II by colorimetric assay using the D-glucose oxidase-peroxidase me... | J Med Chem 41: 2565-71 (1998) Article DOI: 10.1021/jm970836l BindingDB Entry DOI: 10.7270/Q25D8SHK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acidic alpha-glucosidase (Rattus norvegicus) | BDBM50259956 (2,6-Bis-hydroxymethyl-piperidine-3,4,5-triol | CHE...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University Curated by ChEMBL | Assay Description Inhibitory activity measured against alpha-glucosidase of rat intestinal maltase by colorimetric assay using the D-glucose oxidase-peroxidase method | J Med Chem 41: 2565-71 (1998) Article DOI: 10.1021/jm970836l BindingDB Entry DOI: 10.7270/Q25D8SHK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acidic alpha-glucosidase (Rattus norvegicus) | BDBM50259956 (2,6-Bis-hydroxymethyl-piperidine-3,4,5-triol | CHE...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 260 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University Curated by ChEMBL | Assay Description Inhibitory activity measured against alpha-glucosidase of rat liver lysosomal by colorimetric assay using the D-glucose oxidase-peroxidase method | J Med Chem 41: 2565-71 (1998) Article DOI: 10.1021/jm970836l BindingDB Entry DOI: 10.7270/Q25D8SHK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Trehalase (Rattus norvegicus) | BDBM50259956 (2,6-Bis-hydroxymethyl-piperidine-3,4,5-triol | CHE...) | Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University Curated by ChEMBL | Assay Description Inhibitory activity measured against trehalase of porcine kidney by colorimetric assay using the D-glucose oxidase-peroxidase method | J Med Chem 41: 2565-71 (1998) Article DOI: 10.1021/jm970836l BindingDB Entry DOI: 10.7270/Q25D8SHK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Maltase-glucoamylase (Homo sapiens (Human)) | BDBM50259956 (2,6-Bis-hydroxymethyl-piperidine-3,4,5-triol | CHE...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University Curated by ChEMBL | Assay Description Inhibitory activity measured against alpha-glucosidase of rice by colorimetric assay using the D-glucose oxidase-peroxidase method | J Med Chem 41: 2565-71 (1998) Article DOI: 10.1021/jm970836l BindingDB Entry DOI: 10.7270/Q25D8SHK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acidic alpha-glucosidase (Rattus norvegicus) | BDBM50259956 (2,6-Bis-hydroxymethyl-piperidine-3,4,5-triol | CHE...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University Curated by ChEMBL | Assay Description Inhibition of rat intestinal brush border membrane maltase | Bioorg Med Chem 16: 7330-6 (2008) Article DOI: 10.1016/j.bmc.2008.06.026 BindingDB Entry DOI: 10.7270/Q27D2W2B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
alpha-Glucosidase (α-Glucosidase) (Rattus norvegicus (Rat)) | BDBM50259956 (2,6-Bis-hydroxymethyl-piperidine-3,4,5-triol | CHE...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University Curated by ChEMBL | Assay Description Inhibition of rat intestinal brush border membrane isomaltase | Bioorg Med Chem 16: 7330-6 (2008) Article DOI: 10.1016/j.bmc.2008.06.026 BindingDB Entry DOI: 10.7270/Q27D2W2B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
alpha-Glucosidase (α-Glucosidase) (Rattus norvegicus (Rat)) | BDBM50259956 (2,6-Bis-hydroxymethyl-piperidine-3,4,5-triol | CHE...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University Curated by ChEMBL | Assay Description Inhibition of rat intestinal brush border membrane sucrase | Bioorg Med Chem 16: 7330-6 (2008) Article DOI: 10.1016/j.bmc.2008.06.026 BindingDB Entry DOI: 10.7270/Q27D2W2B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysosomal alpha-glucosidase (Homo sapiens (Human)) | BDBM50259956 (2,6-Bis-hydroxymethyl-piperidine-3,4,5-triol | CHE...) | PDB NCI pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University Curated by ChEMBL | Assay Description Inhibition of human lysosomal alpha-glucosidase | Bioorg Med Chem 16: 7330-6 (2008) Article DOI: 10.1016/j.bmc.2008.06.026 BindingDB Entry DOI: 10.7270/Q27D2W2B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glycogen debranching enzyme (Oryctolagus cuniculus) | BDBM50259956 (2,6-Bis-hydroxymethyl-piperidine-3,4,5-triol | CHE...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University Curated by ChEMBL | Assay Description Inhibition of rabbit muscle amylo-1,6-glucosidase | Bioorg Med Chem 16: 7330-6 (2008) Article DOI: 10.1016/j.bmc.2008.06.026 BindingDB Entry DOI: 10.7270/Q27D2W2B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysosomal alpha-glucosidase (Homo sapiens (Human)) | BDBM50259956 (2,6-Bis-hydroxymethyl-piperidine-3,4,5-triol | CHE...) | PDB NCI pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University Curated by ChEMBL | Assay Description Inhibition of maltase in human Caco-2 cell model system after 2 hrs | Bioorg Med Chem 16: 7330-6 (2008) Article DOI: 10.1016/j.bmc.2008.06.026 BindingDB Entry DOI: 10.7270/Q27D2W2B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acidic alpha-glucosidase (Rattus norvegicus) | BDBM50259956 (2,6-Bis-hydroxymethyl-piperidine-3,4,5-triol | CHE...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University Curated by ChEMBL | Assay Description Inhibitory activity measured against alpha-glucosidase of rat intestinal isomaltase by colorimetric assay using the D-glucose oxidase-peroxidase meth... | J Med Chem 41: 2565-71 (1998) Article DOI: 10.1021/jm970836l BindingDB Entry DOI: 10.7270/Q25D8SHK | |||||||||||
More data for this Ligand-Target Pair |