BDBM50260336 CHEMBL4080377

SMILES: CN(C)CCCCC(=O)Nc1ccc(CN(CC(C)(C)C)c2cc(C)nc(C)n2)cc1

InChI Key: InChIKey=HVIDWCICBSEMRB-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50260336   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
G-protein coupled receptor 4 (Mus musculus)	BDBM50260336 (CHEMBL4080377) Show SMILES CN(C)CCCCC(=O)Nc1ccc(CN(CC(C)(C)C)c2cc(C)nc(C)n2)cc1 Show InChI InChI=1S/C25H39N5O/c1-19-16-23(27-20(2)26-19)30(18-25(3,4)5)17-21-11-13-22(14-12-21)28-24(31)10-8-9-15-29(6)7/h11-14,16H,8-10,15,17-18H2,1-7H3,(H,28,31)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	760	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Antagonist activity at mouse GPR4 expressed in HEK cells assessed as inhibition of pH-induced cAMP accumulation preincubated for 15 mins followed by ...				Bioorg Med Chem 25: 4512-4525 (2017) Article DOI: 10.1016/j.bmc.2017.06.050 BindingDB Entry DOI: 10.7270/Q2NS0XB3
					More data for this Ligand-Target Pair
G-protein coupled receptor 4 (Rattus norvegicus)	BDBM50260336 (CHEMBL4080377) Show SMILES CN(C)CCCCC(=O)Nc1ccc(CN(CC(C)(C)C)c2cc(C)nc(C)n2)cc1 Show InChI InChI=1S/C25H39N5O/c1-19-16-23(27-20(2)26-19)30(18-25(3,4)5)17-21-11-13-22(14-12-21)28-24(31)10-8-9-15-29(6)7/h11-14,16H,8-10,15,17-18H2,1-7H3,(H,28,31)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.99E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Antagonist activity at rat GPR4 expressed in HEK cells assessed as inhibition of pH-induced cAMP accumulation preincubated for 15 mins followed by cA...				Bioorg Med Chem 25: 4512-4525 (2017) Article DOI: 10.1016/j.bmc.2017.06.050 BindingDB Entry DOI: 10.7270/Q2NS0XB3
					More data for this Ligand-Target Pair
G-protein coupled receptor 4 (Homo sapiens (Human))	BDBM50260336 (CHEMBL4080377) Show SMILES CN(C)CCCCC(=O)Nc1ccc(CN(CC(C)(C)C)c2cc(C)nc(C)n2)cc1 Show InChI InChI=1S/C25H39N5O/c1-19-16-23(27-20(2)26-19)30(18-25(3,4)5)17-21-11-13-22(14-12-21)28-24(31)10-8-9-15-29(6)7/h11-14,16H,8-10,15,17-18H2,1-7H3,(H,28,31)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Antagonist activity at human GPR4 expressed in African green monkey COS7 cells assessed as inhibition of pH 6.5-induced cAMP accumulation after 30 mi...				Bioorg Med Chem 25: 4512-4525 (2017) Article DOI: 10.1016/j.bmc.2017.06.050 BindingDB Entry DOI: 10.7270/Q2NS0XB3
					More data for this Ligand-Target Pair