BDBM50264483 CHEMBL4105598

SMILES: O=C(NCc1cccs1)c1cnc2c(SSc3cccc4cc(cnc34)C(=O)NCc3cccs3)cccc2c1

InChI Key: InChIKey=AEWRJZQAZXRVBK-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50264483   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
STAM-binding protein (AMSH) (Homo sapiens (Human))	BDBM50264483 (CHEMBL4105598) Show SMILES O=C(NCc1cccs1)c1cnc2c(SSc3cccc4cc(cnc34)C(=O)NCc3cccs3)cccc2c1 Show InChI InChI=1S/C30H22N4O2S4/c35-29(33-17-23-7-3-11-37-23)21-13-19-5-1-9-25(27(19)31-15-21)39-40-26-10-2-6-20-14-22(16-32-28(20)26)30(36)34-18-24-8-4-12-38-24/h1-16H,17-18H2,(H,33,35)(H,34,36)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of California San Diego Curated by ChEMBL					Assay Description Inhibition of AMSH (unknown origin) using DiUbK63TAMRA as substrate by fluorescence assay				J Med Chem 60: 1343-1361 (2017) Article DOI: 10.1021/acs.jmedchem.6b01379 BindingDB Entry DOI: 10.7270/Q22F7QX5
					More data for this Ligand-Target Pair
COP9 signalosome complex subunit 5 (Csn5) (Homo sapiens (Human))	BDBM50264483 (CHEMBL4105598) Show SMILES O=C(NCc1cccs1)c1cnc2c(SSc3cccc4cc(cnc34)C(=O)NCc3cccs3)cccc2c1 Show InChI InChI=1S/C30H22N4O2S4/c35-29(33-17-23-7-3-11-37-23)21-13-19-5-1-9-25(27(19)31-15-21)39-40-26-10-2-6-20-14-22(16-32-28(20)26)30(36)34-18-24-8-4-12-38-24/h1-16H,17-18H2,(H,33,35)(H,34,36)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of California San Diego Curated by ChEMBL					Assay Description Inhibition of CSN5 (unknown origin) using SCFskp2-Nedd8OG as substrate after 1 hr by fluorescence polarization assay				J Med Chem 60: 1343-1361 (2017) Article DOI: 10.1021/acs.jmedchem.6b01379 BindingDB Entry DOI: 10.7270/Q22F7QX5
					More data for this Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11) (Homo sapiens (Human))	BDBM50264483 (CHEMBL4105598) Show SMILES O=C(NCc1cccs1)c1cnc2c(SSc3cccc4cc(cnc34)C(=O)NCc3cccs3)cccc2c1 Show InChI InChI=1S/C30H22N4O2S4/c35-29(33-17-23-7-3-11-37-23)21-13-19-5-1-9-25(27(19)31-15-21)39-40-26-10-2-6-20-14-22(16-32-28(20)26)30(36)34-18-24-8-4-12-38-24/h1-16H,17-18H2,(H,33,35)(H,34,36)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
University of California San Diego Curated by ChEMBL					Assay Description Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated ...				J Med Chem 60: 1343-1361 (2017) Article DOI: 10.1021/acs.jmedchem.6b01379 BindingDB Entry DOI: 10.7270/Q22F7QX5
					More data for this Ligand-Target Pair
26S Proteasome regulatory subunit Rpn11 (Rpn11) (Homo sapiens (Human))	BDBM50264483 (CHEMBL4105598) Show SMILES O=C(NCc1cccs1)c1cnc2c(SSc3cccc4cc(cnc34)C(=O)NCc3cccs3)cccc2c1 Show InChI InChI=1S/C30H22N4O2S4/c35-29(33-17-23-7-3-11-37-23)21-13-19-5-1-9-25(27(19)31-15-21)39-40-26-10-2-6-20-14-22(16-32-28(20)26)30(36)34-18-24-8-4-12-38-24/h1-16H,17-18H2,(H,33,35)(H,34,36)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of California San Diego Curated by ChEMBL					Assay Description Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in beta5 inhibitor MG132 pretreated human HeLa cells expressing UbG76...				J Med Chem 60: 1343-1361 (2017) Article DOI: 10.1021/acs.jmedchem.6b01379 BindingDB Entry DOI: 10.7270/Q22F7QX5
					More data for this Ligand-Target Pair