BindingDB logo
myBDB logout

BDBM50265183 (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-((7-nitrobenzo[c][1,2,5]oxadiazol-4-ylamino)methyl)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol::CHEMBL500899

SMILES: OCC1OC(C(O)C(O)C1O)c1ccc(Cl)c(Cc2ccc(CNc3ccc([N+]([O-])=O)c4[n-][o+]nc34)cc2)c1

InChI Key: InChIKey=PIWCPYZNGJEWKA-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50265183   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50265183
PNG
((2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-((7-nitrobenzo[c...)
Show SMILES OCC1OC(C(O)C(O)C1O)c1ccc(Cl)c(Cc2ccc(CNc3ccc([N+]([O-])=O)c4[n-][o+]nc34)cc2)c1
Show InChI InChI=1S/C26H25ClN4O8/c27-17-6-5-15(26-25(35)24(34)23(33)20(12-32)38-26)10-16(17)9-13-1-3-14(4-2-13)11-28-18-7-8-19(31(36)37)22-21(18)29-39-30-22/h1-8,10,20,23-26,28,32-35H,9,11-12H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2.40E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake by fluorescence polarization assay

Bioorg Med Chem Lett 18: 4944-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.036
BindingDB Entry DOI: 10.7270/Q27944J7
More data for this
Ligand-Target Pair