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BDBM50265218 (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-((methyl(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)methyl)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol::CHEMBL501165

SMILES: CN(Cc1ccc(Cc2cc(ccc2Cl)C2OC(CO)C(O)C(O)C2O)cc1)c1ccc([N+]([O-])=O)c2[n-][o+]nc12

InChI Key: InChIKey=FZOKKEBESXRZHP-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50265218   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50265218
PNG
((2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-((methyl(7-nitro...)
Show SMILES CN(Cc1ccc(Cc2cc(ccc2Cl)C2OC(CO)C(O)C(O)C2O)cc1)c1ccc([N+]([O-])=O)c2[n-][o+]nc12
Show InChI InChI=1S/C27H27ClN4O8/c1-31(19-8-9-20(32(37)38)23-22(19)29-40-30-23)12-15-4-2-14(3-5-15)10-17-11-16(6-7-18(17)28)27-26(36)25(35)24(34)21(13-33)39-27/h2-9,11,21,24-27,33-36H,10,12-13H2,1H3
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PC sid
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Similars
Article
PubMed
n/an/a 286n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake by fluorescence polarization assay

Bioorg Med Chem Lett 18: 4944-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.036
BindingDB Entry DOI: 10.7270/Q27944J7
More data for this
Ligand-Target Pair