BDBM50266789 CHEMBL4088453

SMILES: Cl.NCc1ccnc(Oc2cccc(c2)C(=O)Nc2ccccc2)c1

InChI Key: InChIKey=HWQXLDSAJUNZAU-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50266789   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysyl oxidase (Homo sapiens (Human))	BDBM50266789 (CHEMBL4088453) Show SMILES Cl.NCc1ccnc(Oc2cccc(c2)C(=O)Nc2ccccc2)c1 Show InChI InChI=1S/C19H17N3O2/c20-13-14-9-10-21-18(11-14)24-17-8-4-5-15(12-17)19(23)22-16-6-2-1-3-7-16/h1-12H,13,20H2,(H,22,23)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
PharmAkea Therapeutics Curated by ChEMBL					Assay Description Inhibition of human LOX expressed in HEK cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs foll...				J Med Chem 60: 4403-4423 (2017) Article DOI: 10.1021/acs.jmedchem.7b00345 BindingDB Entry DOI: 10.7270/Q2QV3Q0K
					More data for this Ligand-Target Pair
Lysyl oxidase homolog 2 (Homo sapiens (Human))	BDBM50266789 (CHEMBL4088453) Show SMILES Cl.NCc1ccnc(Oc2cccc(c2)C(=O)Nc2ccccc2)c1 Show InChI InChI=1S/C19H17N3O2/c20-13-14-9-10-21-18(11-14)24-17-8-4-5-15(12-17)19(23)22-16-6-2-1-3-7-16/h1-12H,13,20H2,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	56	n/a	n/a	n/a	n/a	n/a	n/a
PharmAkea Therapeutics Curated by ChEMBL					Assay Description Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...				J Med Chem 60: 4403-4423 (2017) Article DOI: 10.1021/acs.jmedchem.7b00345 BindingDB Entry DOI: 10.7270/Q2QV3Q0K
					More data for this Ligand-Target Pair
Lysyl oxidase homolog 2 (Homo sapiens (Human))	BDBM50266789 (CHEMBL4088453) Show SMILES Cl.NCc1ccnc(Oc2cccc(c2)C(=O)Nc2ccccc2)c1 Show InChI InChI=1S/C19H17N3O2/c20-13-14-9-10-21-18(11-14)24-17-8-4-5-15(12-17)19(23)22-16-6-2-1-3-7-16/h1-12H,13,20H2,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
PharmAkea Therapeutics Curated by ChEMBL					Assay Description Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...				J Med Chem 60: 4403-4423 (2017) Article DOI: 10.1021/acs.jmedchem.7b00345 BindingDB Entry DOI: 10.7270/Q2QV3Q0K
					More data for this Ligand-Target Pair
Lysyl oxidase homolog 2 (Homo sapiens (Human))	BDBM50266789 (CHEMBL4088453) Show SMILES Cl.NCc1ccnc(Oc2cccc(c2)C(=O)Nc2ccccc2)c1 Show InChI InChI=1S/C19H17N3O2/c20-13-14-9-10-21-18(11-14)24-17-8-4-5-15(12-17)19(23)22-16-6-2-1-3-7-16/h1-12H,13,20H2,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
PharmAkea Therapeutics Curated by ChEMBL					Assay Description Inhibition of recombinant human LOXL2 expressed in human whole blood assessed as reduction of H2O2 production from oxidative deamination of DAP prein...				J Med Chem 60: 4403-4423 (2017) Article DOI: 10.1021/acs.jmedchem.7b00345 BindingDB Entry DOI: 10.7270/Q2QV3Q0K
					More data for this Ligand-Target Pair