BDBM50266795 CHEMBL4063420
SMILES: Cl.NCc1ccnc(Oc2cccc(c2)C(=O)Nc2ccc(cc2)C(O)=O)c1
InChI Key: InChIKey=ICUFXLHEFRTNQM-UHFFFAOYSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Lysyl oxidase homolog 2 (Homo sapiens (Human)) | BDBM50266795 (CHEMBL4063420) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
PharmAkea Therapeutics Curated by ChEMBL | Assay Description Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo... | J Med Chem 60: 4403-4423 (2017) Article DOI: 10.1021/acs.jmedchem.7b00345 BindingDB Entry DOI: 10.7270/Q2QV3Q0K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysyl oxidase (Homo sapiens (Human)) | BDBM50266795 (CHEMBL4063420) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
PharmAkea Therapeutics Curated by ChEMBL | Assay Description Inhibition of human LOX expressed in HEK cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs foll... | J Med Chem 60: 4403-4423 (2017) Article DOI: 10.1021/acs.jmedchem.7b00345 BindingDB Entry DOI: 10.7270/Q2QV3Q0K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysyl oxidase homolog 2 (Homo sapiens (Human)) | BDBM50266795 (CHEMBL4063420) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 81 | n/a | n/a | n/a | n/a | n/a | n/a |
PharmAkea Therapeutics Curated by ChEMBL | Assay Description Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo... | J Med Chem 60: 4403-4423 (2017) Article DOI: 10.1021/acs.jmedchem.7b00345 BindingDB Entry DOI: 10.7270/Q2QV3Q0K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysyl oxidase homolog 2 (Homo sapiens (Human)) | BDBM50266795 (CHEMBL4063420) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
PharmAkea Therapeutics Curated by ChEMBL | Assay Description Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo... | J Med Chem 60: 4403-4423 (2017) Article DOI: 10.1021/acs.jmedchem.7b00345 BindingDB Entry DOI: 10.7270/Q2QV3Q0K | |||||||||||
More data for this Ligand-Target Pair |