BDBM50266838 CHEMBL4084982
SMILES: Cl.NCc1cc(Oc2cccc(c2)C(=O)NCCS(N)(=O)=O)nc(c1)C(F)(F)F
InChI Key: InChIKey=LIDBMZYKSAXTQG-UHFFFAOYSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Lysyl oxidase homolog 2 (Homo sapiens (Human)) | BDBM50266838 (CHEMBL4084982) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 310 | n/a | n/a | n/a | n/a | n/a | n/a |
PharmAkea Therapeutics Curated by ChEMBL | Assay Description Inhibition of recombinant human LOXL2 expressed in human whole blood assessed as reduction of H2O2 production from oxidative deamination of DAP prein... | J Med Chem 60: 4403-4423 (2017) Article DOI: 10.1021/acs.jmedchem.7b00345 BindingDB Entry DOI: 10.7270/Q2QV3Q0K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysyl oxidase (Homo sapiens (Human)) | BDBM50266838 (CHEMBL4084982) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
PharmAkea Therapeutics Curated by ChEMBL | Assay Description Inhibition of human LOX expressed in HEK cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs foll... | J Med Chem 60: 4403-4423 (2017) Article DOI: 10.1021/acs.jmedchem.7b00345 BindingDB Entry DOI: 10.7270/Q2QV3Q0K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysyl oxidase homolog 2 (Homo sapiens (Human)) | BDBM50266838 (CHEMBL4084982) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
PharmAkea Therapeutics Curated by ChEMBL | Assay Description Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo... | J Med Chem 60: 4403-4423 (2017) Article DOI: 10.1021/acs.jmedchem.7b00345 BindingDB Entry DOI: 10.7270/Q2QV3Q0K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysyl oxidase homolog 2 (Homo sapiens (Human)) | BDBM50266838 (CHEMBL4084982) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 62 | n/a | n/a | n/a | n/a | n/a | n/a |
PharmAkea Therapeutics Curated by ChEMBL | Assay Description Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo... | J Med Chem 60: 4403-4423 (2017) Article DOI: 10.1021/acs.jmedchem.7b00345 BindingDB Entry DOI: 10.7270/Q2QV3Q0K | |||||||||||
More data for this Ligand-Target Pair |