BDBM50267304 CHEMBL4099377

SMILES: COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncnc(-c2cn(C)c3ccccc23)c1F

InChI Key: InChIKey=VSMNNTUATHZMKB-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50267304   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50267304 (CHEMBL4099377) Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncnc(-c2cn(C)c3ccccc23)c1F Show InChI InChI=1S/C28H32FN7O2/c1-7-25(37)32-20-14-21(24(38-6)15-23(20)35(4)13-12-34(2)3)33-28-26(29)27(30-17-31-28)19-16-36(5)22-11-9-8-10-18(19)22/h7-11,14-17H,1,12-13H2,2-6H3,(H,32,37)(H,30,31,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing Normal University Curated by ChEMBL					Assay Description Inhibition of human recombinant cytoplasmic GST-tagged EGFR (668 to 1210 residues) expressed in baculovirus using TK-substrate-biotin preincubated fo...				Eur J Med Chem 135: 12-23 (2017) Article DOI: 10.1016/j.ejmech.2017.04.036 BindingDB Entry DOI: 10.7270/Q28P630H
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