BDBM50269377 CHEMBL4093021

SMILES: CC(C)(C)c1cc2ncnc(-n3nc(Nc4ccc(N5CCN(CC5)C5CC6CCC5C6)c(Cl)c4)nc3N)c2s1

InChI Key: InChIKey=MBRAACMFVDEVED-UHFFFAOYSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50269377   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50269377 (CHEMBL4093021) Show SMILES CC(C)(C)c1cc2ncnc(-n3nc(Nc4ccc(N5CCN(CC5)C5CC6CCC5C6)c(Cl)c4)nc3N)c2s1 |THB:22:25:28.29:31| Show InChI InChI=1S/C29H36ClN9S/c1-29(2,3)24-15-21-25(40-24)26(33-16-32-21)39-27(31)35-28(36-39)34-19-6-7-22(20(30)14-19)37-8-10-38(11-9-37)23-13-17-4-5-18(23)12-17/h6-7,14-18,23H,4-5,8-13H2,1-3H3,(H3,31,34,35,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	80	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, 1180 Veterans Blvd., South San Francisco, CA 94080, USA. Electronic address: dagoff@att.net. Curated by ChEMBL					Assay Description Inhibition of VEGF stimulated VEGFR2 phosphorylation at Y165 residues in HUVEC preincubated for 1 hr followed by VEGF addition measured after 5 mins ...				Bioorg Med Chem Lett 27: 3766-3771 (2017) Article DOI: 10.1016/j.bmcl.2017.06.071 BindingDB Entry DOI: 10.7270/Q26D5WH0
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM50269377 (CHEMBL4093021) Show SMILES CC(C)(C)c1cc2ncnc(-n3nc(Nc4ccc(N5CCN(CC5)C5CC6CCC5C6)c(Cl)c4)nc3N)c2s1 |THB:22:25:28.29:31| Show InChI InChI=1S/C29H36ClN9S/c1-29(2,3)24-15-21-25(40-24)26(33-16-32-21)39-27(31)35-28(36-39)34-19-6-7-22(20(30)14-19)37-8-10-38(11-9-37)23-13-17-4-5-18(23)12-17/h6-7,14-18,23H,4-5,8-13H2,1-3H3,(H3,31,34,35,36)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	84	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, 1180 Veterans Blvd., South San Francisco, CA 94080, USA. Electronic address: dagoff@att.net. Curated by ChEMBL					Assay Description Inhibition of Axl in human HeLa cells assessed as reduction in AKT phosphorylation at Ser 473 residues pre-incubated for 1 hr before preclustered ant...				Bioorg Med Chem Lett 27: 3766-3771 (2017) Article DOI: 10.1016/j.bmcl.2017.06.071 BindingDB Entry DOI: 10.7270/Q26D5WH0
					More data for this Ligand-Target Pair