BDBM50269382 CHEMBL4071540

SMILES: [H][C@]12CC[C@]([H])(C1)[C@@H](C2)N1CCN(CC1)c1ccc(Nc2nc(N)n(n2)-c2nc(Cl)nc3c(C)csc23)cc1Cl

InChI Key: InChIKey=VMMYOXWMJSIMQE-RZQQEMMASA-N

Data: 1 EC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50269382   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM50269382 (CHEMBL4071540) Show SMILES [H][C@]12CC[C@]([H])(C1)[C@@H](C2)N1CCN(CC1)c1ccc(Nc2nc(N)n(n2)-c2nc(Cl)nc3c(C)csc23)cc1Cl |r,THB:9:7:2.3:6| Show InChI InChI=1S/C26H29Cl2N9S/c1-14-13-38-22-21(14)31-24(28)32-23(22)37-25(29)33-26(34-37)30-17-4-5-19(18(27)12-17)35-6-8-36(9-7-35)20-11-15-2-3-16(20)10-15/h4-5,12-13,15-16,20H,2-3,6-11H2,1H3,(H3,29,30,33,34)/t15-,16+,20+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	216	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, 1180 Veterans Blvd., South San Francisco, CA 94080, USA. Electronic address: dagoff@att.net. Curated by ChEMBL					Assay Description Inhibition of Axl in human HeLa cells assessed as reduction in AKT phosphorylation at Ser 473 residues pre-incubated for 1 hr before preclustered ant...				Bioorg Med Chem Lett 27: 3766-3771 (2017) Article DOI: 10.1016/j.bmcl.2017.06.071 BindingDB Entry DOI: 10.7270/Q26D5WH0
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