BDBM50269394 CHEMBL4095789

SMILES: Nc1nc(Nc2ccc(cc2)N2CCN(CC2)C2CC3CCC2C3)nn1-c1ncnc2ccc(F)cc12

InChI Key: InChIKey=FJOGCOQDUBZENL-UHFFFAOYSA-N

Data: 1 IC50  2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50269394   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50269394 (CHEMBL4095789) Show SMILES Nc1nc(Nc2ccc(cc2)N2CCN(CC2)C2CC3CCC2C3)nn1-c1ncnc2ccc(F)cc12 |THB:14:17:20.21:23| Show InChI InChI=1S/C27H30FN9/c28-19-3-8-23-22(15-19)25(31-16-30-23)37-26(29)33-27(34-37)32-20-4-6-21(7-5-20)35-9-11-36(12-10-35)24-14-17-1-2-18(24)13-17/h3-8,15-18,24H,1-2,9-14H2,(H3,29,32,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	146	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, 1180 Veterans Blvd., South San Francisco, CA 94080, USA. Electronic address: dagoff@att.net. Curated by ChEMBL					Assay Description Inhibition of VEGF stimulated VEGFR2 phosphorylation at Y165 residues in HUVEC preincubated for 1 hr followed by VEGF addition measured after 5 mins ...				Bioorg Med Chem Lett 27: 3766-3771 (2017) Article DOI: 10.1016/j.bmcl.2017.06.071 BindingDB Entry DOI: 10.7270/Q26D5WH0
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM50269394 (CHEMBL4095789) Show SMILES Nc1nc(Nc2ccc(cc2)N2CCN(CC2)C2CC3CCC2C3)nn1-c1ncnc2ccc(F)cc12 |THB:14:17:20.21:23| Show InChI InChI=1S/C27H30FN9/c28-19-3-8-23-22(15-19)25(31-16-30-23)37-26(29)33-27(34-37)32-20-4-6-21(7-5-20)35-9-11-36(12-10-35)24-14-17-1-2-18(24)13-17/h3-8,15-18,24H,1-2,9-14H2,(H3,29,32,33,34)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, 1180 Veterans Blvd., South San Francisco, CA 94080, USA. Electronic address: dagoff@att.net. Curated by ChEMBL					Assay Description Inhibition of N-terminal GST-tagged human Axl (464 to 885 end residues) cytoplasmic domain expressed in baculovirus expression system using HS1 pepti...				Bioorg Med Chem Lett 27: 3766-3771 (2017) Article DOI: 10.1016/j.bmcl.2017.06.071 BindingDB Entry DOI: 10.7270/Q26D5WH0
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM50269394 (CHEMBL4095789) Show SMILES Nc1nc(Nc2ccc(cc2)N2CCN(CC2)C2CC3CCC2C3)nn1-c1ncnc2ccc(F)cc12 |THB:14:17:20.21:23| Show InChI InChI=1S/C27H30FN9/c28-19-3-8-23-22(15-19)25(31-16-30-23)37-26(29)33-27(34-37)32-20-4-6-21(7-5-20)35-9-11-36(12-10-35)24-14-17-1-2-18(24)13-17/h3-8,15-18,24H,1-2,9-14H2,(H3,29,32,33,34)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	253	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, 1180 Veterans Blvd., South San Francisco, CA 94080, USA. Electronic address: dagoff@att.net. Curated by ChEMBL					Assay Description Inhibition of Axl in human HeLa cells assessed as reduction in AKT phosphorylation at Ser 473 residues pre-incubated for 1 hr before preclustered ant...				Bioorg Med Chem Lett 27: 3766-3771 (2017) Article DOI: 10.1016/j.bmcl.2017.06.071 BindingDB Entry DOI: 10.7270/Q26D5WH0
					More data for this Ligand-Target Pair