BDBM50269703 CHEMBL4089866

SMILES: CC(N1CCC(CC1)N(C)C(=O)c1cn(CC=C)c(=O)c2[nH]ccc12)c1ccccc1

InChI Key: InChIKey=OGCZSQWQJLMMAE-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50269703   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bromodomain-containing protein 9 (Homo sapiens (Human))	BDBM50269703 (CHEMBL4089866) Show SMILES CC(N1CCC(CC1)N(C)C(=O)c1cn(CC=C)c(=O)c2[nH]ccc12)c1ccccc1 Show InChI InChI=1S/C25H30N4O2/c1-4-14-29-17-22(21-10-13-26-23(21)25(29)31)24(30)27(3)20-11-15-28(16-12-20)18(2)19-8-6-5-7-9-19/h4-10,13,17-18,20,26H,1,11-12,14-16H2,2-3H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States. Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal His6-FLAG-tagged BRD9 (unknown origin) expressed in Rosetta2 (DE3) pLysS cells after 60 mins by TR-FRET as...				ACS Med Chem Lett 8: 737-741 (2017) Article DOI: 10.1021/acsmedchemlett.7b00132 BindingDB Entry DOI: 10.7270/Q2862JXN
					More data for this Ligand-Target Pair
Transcription initiation factor TFIID subunit 1 (Homo sapiens (Human))	BDBM50269703 (CHEMBL4089866) Show SMILES CC(N1CCC(CC1)N(C)C(=O)c1cn(CC=C)c(=O)c2[nH]ccc12)c1ccccc1 Show InChI InChI=1S/C25H30N4O2/c1-4-14-29-17-22(21-10-13-26-23(21)25(29)31)24(30)27(3)20-11-15-28(16-12-20)18(2)19-8-6-5-7-9-19/h4-10,13,17-18,20,26H,1,11-12,14-16H2,2-3H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.61E+4	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States. Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal His6-FLAG-tagged TAF1 bromodomain 2 (unknown origin) expressed in Rosetta2 (DE3) pLysS cells after 60 mins...				ACS Med Chem Lett 8: 737-741 (2017) Article DOI: 10.1021/acsmedchemlett.7b00132 BindingDB Entry DOI: 10.7270/Q2862JXN
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 (Homo sapiens (Human))	BDBM50269703 (CHEMBL4089866) Show SMILES CC(N1CCC(CC1)N(C)C(=O)c1cn(CC=C)c(=O)c2[nH]ccc12)c1ccccc1 Show InChI InChI=1S/C25H30N4O2/c1-4-14-29-17-22(21-10-13-26-23(21)25(29)31)24(30)27(3)20-11-15-28(16-12-20)18(2)19-8-6-5-7-9-19/h4-10,13,17-18,20,26H,1,11-12,14-16H2,2-3H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States. Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal His6-FLAG-tagged BRD4 bromodomain 2 (unknown origin) expressed in Rosetta2 (DE3) pLysS cells after 60 mins...				ACS Med Chem Lett 8: 737-741 (2017) Article DOI: 10.1021/acsmedchemlett.7b00132 BindingDB Entry DOI: 10.7270/Q2862JXN
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 (Homo sapiens (Human))	BDBM50269703 (CHEMBL4089866) Show SMILES CC(N1CCC(CC1)N(C)C(=O)c1cn(CC=C)c(=O)c2[nH]ccc12)c1ccccc1 Show InChI InChI=1S/C25H30N4O2/c1-4-14-29-17-22(21-10-13-26-23(21)25(29)31)24(30)27(3)20-11-15-28(16-12-20)18(2)19-8-6-5-7-9-19/h4-10,13,17-18,20,26H,1,11-12,14-16H2,2-3H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States. Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal His6-FLAG-tagged BRD4 bromodomain 1 expressed in Rosetta2 (DE3) pLysS cells after 60 mins by TR-FRET assay				ACS Med Chem Lett 8: 737-741 (2017) Article DOI: 10.1021/acsmedchemlett.7b00132 BindingDB Entry DOI: 10.7270/Q2862JXN
					More data for this Ligand-Target Pair
Cat eye syndrome critical region protein 2 (Homo sapiens (Human))	BDBM50269703 (CHEMBL4089866) Show SMILES CC(N1CCC(CC1)N(C)C(=O)c1cn(CC=C)c(=O)c2[nH]ccc12)c1ccccc1 Show InChI InChI=1S/C25H30N4O2/c1-4-14-29-17-22(21-10-13-26-23(21)25(29)31)24(30)27(3)20-11-15-28(16-12-20)18(2)19-8-6-5-7-9-19/h4-10,13,17-18,20,26H,1,11-12,14-16H2,2-3H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States. Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal His6-FLAG-tagged CECR2 expressed in Rosetta2 (DE3) pLysS cells after 60 mins by TR-FRET assay				ACS Med Chem Lett 8: 737-741 (2017) Article DOI: 10.1021/acsmedchemlett.7b00132 BindingDB Entry DOI: 10.7270/Q2862JXN
					More data for this Ligand-Target Pair