Found 7 hits for monomerid = 50272643 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50272643
(((3R,4R)-4-(2-chlorophenoxy)-3,4-dihydro-2H-chrome...)Show InChI InChI=1S/C17H18ClNO2/c1-19-10-12-11-20-15-8-4-2-6-13(15)17(12)21-16-9-5-3-7-14(16)18/h2-9,12,17,19H,10-11H2,1H3/t12-,17-/m1/s1 | NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description Inhibition of dopamine uptake at human DAT expressed in HEK cells |
Bioorg Med Chem Lett 18: 4495-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.050 BindingDB Entry DOI: 10.7270/Q2VH5NP8 |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50272643
(((3R,4R)-4-(2-chlorophenoxy)-3,4-dihydro-2H-chrome...)Show InChI InChI=1S/C17H18ClNO2/c1-19-10-12-11-20-15-8-4-2-6-13(15)17(12)21-16-9-5-3-7-14(16)18/h2-9,12,17,19H,10-11H2,1H3/t12-,17-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description Inhibition of norepinephrine uptake at human NET expressed in HEK cells |
Bioorg Med Chem Lett 18: 4495-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.050 BindingDB Entry DOI: 10.7270/Q2VH5NP8 |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50272643
(((3R,4R)-4-(2-chlorophenoxy)-3,4-dihydro-2H-chrome...)Show InChI InChI=1S/C17H18ClNO2/c1-19-10-12-11-20-15-8-4-2-6-13(15)17(12)21-16-9-5-3-7-14(16)18/h2-9,12,17,19H,10-11H2,1H3/t12-,17-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description Inhibition of serotonin uptake at human SERT expressed in HEK cells |
Bioorg Med Chem Lett 18: 4495-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.050 BindingDB Entry DOI: 10.7270/Q2VH5NP8 |
More data for this Ligand-Target Pair | |
Cytochrome P450 2D6
(Homo sapiens (Human)) | BDBM50272643
(((3R,4R)-4-(2-chlorophenoxy)-3,4-dihydro-2H-chrome...)Show InChI InChI=1S/C17H18ClNO2/c1-19-10-12-11-20-15-8-4-2-6-13(15)17(12)21-16-9-5-3-7-14(16)18/h2-9,12,17,19H,10-11H2,1H3/t12-,17-/m1/s1 | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description Inhibition of recombinant CYP32D6 |
Bioorg Med Chem Lett 18: 4491-4 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.049 BindingDB Entry DOI: 10.7270/Q2S75H8V |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50272643
(((3R,4R)-4-(2-chlorophenoxy)-3,4-dihydro-2H-chrome...)Show InChI InChI=1S/C17H18ClNO2/c1-19-10-12-11-20-15-8-4-2-6-13(15)17(12)21-16-9-5-3-7-14(16)18/h2-9,12,17,19H,10-11H2,1H3/t12-,17-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description Inhibition of serotonin uptake at human SERT expressed in HEK293 cells |
Bioorg Med Chem Lett 18: 4491-4 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.049 BindingDB Entry DOI: 10.7270/Q2S75H8V |
More data for this Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50272643
(((3R,4R)-4-(2-chlorophenoxy)-3,4-dihydro-2H-chrome...)Show InChI InChI=1S/C17H18ClNO2/c1-19-10-12-11-20-15-8-4-2-6-13(15)17(12)21-16-9-5-3-7-14(16)18/h2-9,12,17,19H,10-11H2,1H3/t12-,17-/m1/s1 | NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description Inhibition of dopamine uptake at human DAT expressed in HEK293 cells |
Bioorg Med Chem Lett 18: 4491-4 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.049 BindingDB Entry DOI: 10.7270/Q2S75H8V |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50272643
(((3R,4R)-4-(2-chlorophenoxy)-3,4-dihydro-2H-chrome...)Show InChI InChI=1S/C17H18ClNO2/c1-19-10-12-11-20-15-8-4-2-6-13(15)17(12)21-16-9-5-3-7-14(16)18/h2-9,12,17,19H,10-11H2,1H3/t12-,17-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description Inhibition of norepinephrine uptake at human NET expressed in HEK293 cells |
Bioorg Med Chem Lett 18: 4491-4 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.049 BindingDB Entry DOI: 10.7270/Q2S75H8V |
More data for this Ligand-Target Pair | |