null

SMILES: CN[C@@H](Cn1c(=O)c(c(C)n(Cc2c(F)cccc2C(F)(F)F)c1=O)-c1cccc(OCCN(C)CC(O)=O)c1F)c1ccccc1

InChI Key: InChIKey=LINFTOFILYRPLU-SANMLTNESA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50272669   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50272669 ((R)-2-((2-(3-(1-(2-fluoro-6-(trifluoromethyl)benzy...) Show SMILES CN[C@@H](Cn1c(=O)c(c(C)n(Cc2c(F)cccc2C(F)(F)F)c1=O)-c1cccc(OCCN(C)CC(O)=O)c1F)c1ccccc1 |r,wD:2.1,(32.28,-29.82,;33.61,-29.04,;33.61,-27.5,;34.94,-26.73,;36.28,-27.49,;37.6,-26.72,;37.6,-25.18,;38.93,-27.49,;38.93,-29.03,;40.27,-29.81,;37.6,-29.8,;37.6,-31.34,;36.82,-32.67,;37.65,-33.95,;39.19,-33.87,;36.96,-35.32,;35.41,-35.4,;34.58,-34.1,;35.28,-32.73,;34.45,-31.44,;33.63,-30.13,;33.15,-32.26,;35.75,-30.61,;36.28,-29.03,;34.94,-29.81,;40.26,-26.73,;41.59,-27.51,;42.93,-26.74,;42.94,-25.2,;41.59,-24.43,;41.59,-22.89,;42.93,-22.12,;42.93,-20.58,;44.26,-19.81,;45.59,-20.58,;44.26,-18.27,;45.59,-17.5,;46.93,-18.26,;45.59,-15.95,;40.26,-25.2,;38.93,-24.43,;32.27,-26.74,;32.28,-25.2,;30.94,-24.43,;29.61,-25.21,;29.62,-26.75,;30.95,-27.51,)| Show InChI InChI=1S/C33H33F5N4O5/c1-20-29(22-11-7-14-27(30(22)35)47-16-15-40(3)19-28(43)44)31(45)42(18-26(39-2)21-9-5-4-6-10-21)32(46)41(20)17-23-24(33(36,37)38)12-8-13-25(23)34/h4-14,26,39H,15-19H2,1-3H3,(H,43,44)/t26-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	98	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I]tyr5,D-Leu6,NMeLeu7-GnRH from human cloned GnRH receptor expressed in RBL cells				Bioorg Med Chem Lett 18: 4503-7 (2008) Article DOI: 10.1016/j.bmcl.2008.07.059 BindingDB Entry DOI: 10.7270/Q2QR4WZJ
					More data for this Ligand-Target Pair