BindingDB PrimarySearch

BDBM50273009 CHEMBL4129809

SMILES: N[C@@H]1CCCN(C1)[C@@H]1Cc2ccccc2[C@H]1Oc1ccc(cc1Cl)C#N

InChI Key: InChIKey=RLKRLNQEXBPQGQ-OZOXKJRCSA-N

Data: 7 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50273009
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM50273009 (CHEMBL4129809) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	9.5	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Co., Ltd Curated by ChEMBL					Assay Description Inhibition of human TRPC6 expressed in HEK293 cells assessed as decrease in intracellular calcium level after 24 hrs by Fluo-4 dye-based FLIPR assay				Bioorg Med Chem Lett 28: 2222-2227 (2018) Article DOI: 10.1016/j.bmcl.2018.03.056 BindingDB Entry DOI: 10.7270/Q2CF9SMH
Daiichi Sankyo Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Short transient receptor potential channel 7 (Homo sapiens)	BDBM50273009 (CHEMBL4129809) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	226	n/a	n/a	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Inhibition of human TRPC7 expressed in HEK293 cells assessed as reduction in OAG-induced calcium influx after 10 mins by fluo-4/AM dye based FLIPR as...				J Med Chem 62: 7589-7602 (2019) Article DOI: 10.1021/acs.jmedchem.8b01954
University of Nebraska Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM50273009 (CHEMBL4129809) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	7.90	n/a	n/a	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Inhibition of human TRPC6 expressed in HEK293 cells assessed as reduction in TRPC6-induced current by Whole-cell patch-clamp				J Med Chem 62: 7589-7602 (2019) Article DOI: 10.1021/acs.jmedchem.8b01954
University of Nebraska Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Short transient receptor potential channel 3 (Homo sapiens (Human))	BDBM50273009 (CHEMBL4129809) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	282	n/a	n/a	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Inhibition of human TRPC3 expressed in CHO cells assessed as reduction in OAG-induced calcium influx after 10 mins by fluo-4/AM dye based FLIPR assay				J Med Chem 62: 7589-7602 (2019) Article DOI: 10.1021/acs.jmedchem.8b01954
University of Nebraska Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Short transient receptor potential channel 6 (Homo sapiens (Human))	BDBM50273009 (CHEMBL4129809) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	9.5	n/a	n/a	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Inhibition of human TRPC6 expressed in HEK293 cells assessed as reduction in OAG-induced calcium influx after 10 mins by fluo-4/AM dye based FLIPR as...				J Med Chem 62: 7589-7602 (2019) Article DOI: 10.1021/acs.jmedchem.8b01954
University of Nebraska Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Short transient receptor potential channel 5 (Mus musculus)	BDBM50273009 (CHEMBL4129809) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Inhibition of mouse TRPC5 by FLIPR assay				J Med Chem 62: 7589-7602 (2019) Article DOI: 10.1021/acs.jmedchem.8b01954
University of Nebraska Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
alternatively spliced Trp4 (Mus musculus)	BDBM50273009 (CHEMBL4129809) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Inhibition of mouse TRPC4 by FLIPR assay				J Med Chem 62: 7589-7602 (2019) Article DOI: 10.1021/acs.jmedchem.8b01954
University of Nebraska Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair