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BDBM50273646 CHEMBL4126698

SMILES: Cc1noc(C)c1-c1cc(O)cc(c1)C(O)c1ccc(Cl)cn1

InChI Key: InChIKey=HDZUDLHMKDHTLY-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50273646   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50273646
PNG
(CHEMBL4126698)
Show SMILES Cc1noc(C)c1-c1cc(O)cc(c1)C(O)c1ccc(Cl)cn1
Show InChI InChI=1S/C17H15ClN2O3/c1-9-16(10(2)23-20-9)11-5-12(7-14(21)6-11)17(22)15-4-3-13(18)8-19-15/h3-8,17,21-22H,1-2H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 495n/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of recombinant His6-tagged human BRD4 bromodomain 1 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells preincubated for 30 mins follo...


Bioorg Med Chem 26: 2937-2957 (2018)


Article DOI: 10.1016/j.bmc.2018.05.003
BindingDB Entry DOI: 10.7270/Q2Z89FXZ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50273646
PNG
(CHEMBL4126698)
Show SMILES Cc1noc(C)c1-c1cc(O)cc(c1)C(O)c1ccc(Cl)cn1
Show InChI InChI=1S/C17H15ClN2O3/c1-9-16(10(2)23-20-9)11-5-12(7-14(21)6-11)17(22)15-4-3-13(18)8-19-15/h3-8,17,21-22H,1-2H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 490n/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of recombinant His6-tagged human BRD4 bromodomain 1 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells preincubated for 30 mins follo...


Bioorg Med Chem 26: 2937-2957 (2018)


Article DOI: 10.1016/j.bmc.2018.05.003
BindingDB Entry DOI: 10.7270/Q2Z89FXZ
More data for this
Ligand-Target Pair