BDBM50274574 CHEMBL4128211

SMILES: COc1ccc(cc1OC)-c1ccc2C(=O)N(Cc2c1)c1cccc(CC#N)c1

InChI Key: InChIKey=BLJYMHUQTWGYDK-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50274574   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM50274574 (CHEMBL4128211) Show SMILES COc1ccc(cc1OC)-c1ccc2C(=O)N(Cc2c1)c1cccc(CC#N)c1 Show InChI InChI=1S/C24H20N2O3/c1-28-22-9-7-18(14-23(22)29-2)17-6-8-21-19(13-17)15-26(24(21)27)20-5-3-4-16(12-20)10-11-25/h3-9,12-14H,10,15H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	160	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc Curated by ChEMBL					Assay Description Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate after 15 mins in presence of [33P-ATP] by liquid scintillation counting method				J Med Chem 61: 5245-5256 (2018) Article DOI: 10.1021/acs.jmedchem.8b00085 BindingDB Entry DOI: 10.7270/Q2V98BK8
					More data for this Ligand-Target Pair