Found 5 hits for monomerid = 50274658 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50274658
![PNG](/data/jpeg/tenK5027/BindingDB_50274658.png) (CHEMBL4128809)Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(C)c2C1=O)-c1nccnc1N |r| Show InChI InChI=1S/C18H20N4O/c1-10-7-13(16-17(19)21-6-5-20-16)8-14-9-22(18(23)15(10)14)11(2)12-3-4-12/h5-8,11-12H,3-4,9H2,1-2H3,(H2,19,21)/t11-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaron-Beijing Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of recombinant human 6His-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 10 mins followed by substr... |
J Med Chem 61: 5435-5441 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00447 BindingDB Entry DOI: 10.7270/Q27M0BFZ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50274658
![PNG](/data/jpeg/tenK5027/BindingDB_50274658.png) (CHEMBL4128809)Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(C)c2C1=O)-c1nccnc1N |r| Show InChI InChI=1S/C18H20N4O/c1-10-7-13(16-17(19)21-6-5-20-16)8-14-9-22(18(23)15(10)14)11(2)12-3-4-12/h5-8,11-12H,3-4,9H2,1-2H3,(H2,19,21)/t11-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | <3.16E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaron-Beijing Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of recombinant human 6His-tagged PI3K p110beta/p85alpha using DiC8-PIP2 as substrate preincubated for 10 mins followed by substrate additi... |
J Med Chem 61: 5435-5441 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00447 BindingDB Entry DOI: 10.7270/Q27M0BFZ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Mus musculus (Mouse)) | BDBM50274658
![PNG](/data/jpeg/tenK5027/BindingDB_50274658.png) (CHEMBL4128809)Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(C)c2C1=O)-c1nccnc1N |r| Show InChI InChI=1S/C18H20N4O/c1-10-7-13(16-17(19)21-6-5-20-16)8-14-9-22(18(23)15(10)14)11(2)12-3-4-12/h5-8,11-12H,3-4,9H2,1-2H3,(H2,19,21)/t11-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.94E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaron-Beijing Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of PI3Kgamma in mouse RAW264 cells assessed as reduction in Akt phosphorylation at Ser473 residue preincubated for 15 mins followed by C5a... |
J Med Chem 61: 5435-5441 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00447 BindingDB Entry DOI: 10.7270/Q27M0BFZ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50274658
![PNG](/data/jpeg/tenK5027/BindingDB_50274658.png) (CHEMBL4128809)Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(C)c2C1=O)-c1nccnc1N |r| Show InChI InChI=1S/C18H20N4O/c1-10-7-13(16-17(19)21-6-5-20-16)8-14-9-22(18(23)15(10)14)11(2)12-3-4-12/h5-8,11-12H,3-4,9H2,1-2H3,(H2,19,21)/t11-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | <3.16E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaron-Beijing Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of recombinant human 6His-tagged PI3K p110alpha/p85alpha using DiC8-PIP2 as substrate preincubated for 10 mins followed by substrate addit... |
J Med Chem 61: 5435-5441 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00447 BindingDB Entry DOI: 10.7270/Q27M0BFZ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50274658
![PNG](/data/jpeg/tenK5027/BindingDB_50274658.png) (CHEMBL4128809)Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(C)c2C1=O)-c1nccnc1N |r| Show InChI InChI=1S/C18H20N4O/c1-10-7-13(16-17(19)21-6-5-20-16)8-14-9-22(18(23)15(10)14)11(2)12-3-4-12/h5-8,11-12H,3-4,9H2,1-2H3,(H2,19,21)/t11-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaron-Beijing Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of recombinant human 6His-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 10 mins followed by substrate addit... |
J Med Chem 61: 5435-5441 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00447 BindingDB Entry DOI: 10.7270/Q27M0BFZ |
More data for this Ligand-Target Pair | |