BDBM50276045 (R)-3-Amino-4-(5-chloro-2-fluoro-phenyl)-N-{4-[6-(2-methoxy-ethoxy)-benzothiazol-2-yl]-1,1-dioxo-hexahydro-1lambda*6*-thiopyran-4-yl}-butyramide::CHEMBL512651
SMILES: COCCOc1ccc2nc(sc2c1)C1(CCS(=O)(=O)CC1)NC(=O)C[C@H](N)Cc1cc(Cl)ccc1F
InChI Key: InChIKey=NNPQTJRIAUTXFQ-GOSISDBHSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dipeptidyl peptidase 4 (Homo sapiens (Human)) | BDBM50276045 ((R)-3-Amino-4-(5-chloro-2-fluoro-phenyl)-N-{4-[6-(...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.640 | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries Inc. Curated by ChEMBL | Assay Description Inhibition of human Caco2 cells-derived DPP4 | Bioorg Med Chem Lett 18: 5435-8 (2008) Article DOI: 10.1016/j.bmcl.2008.09.042 BindingDB Entry DOI: 10.7270/Q2QV3MC8 | |||||||||||
More data for this Ligand-Target Pair |