BDBM50277491 CHEMBL504955::Lumi-4alpha-Phorbol 12,13-didecanoate

SMILES: CCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@@]2(O)[C@H]([C@@H]3C(C)(C)[C@]13OC(=O)CCCCCCCCC)C1C3[C@@H]2[C@H]2CC1(CO)C3(C)C2=O

InChI Key: InChIKey=CRKYLQFXMOPIAZ-FDTHMRAFSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50277491   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily V member 4 (Mus musculus)	BDBM50277491 (CHEMBL504955 | Lumi-4alpha-Phorbol 12,13-didecanoa...) Show SMILES CCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@@]2(O)[C@H]([C@@H]3C(C)(C)[C@]13OC(=O)CCCCCCCCC)C1C3[C@@H]2[C@H]2CC1(CO)C3(C)C2=O |r,THB:46:45:39.40:37.36| Show InChI InChI=1S/C40H64O7/c1-7-9-11-13-15-17-19-21-27(42)46-35-25(3)39(45)29-26-23-38(24-41)31(30(29)37(38,6)34(26)44)32(39)33-36(4,5)40(33,35)47-28(43)22-20-18-16-14-12-10-8-2/h25-26,29-33,35,41,45H,7-24H2,1-6H3/t25-,26-,29+,30?,31?,32+,33?,35-,37?,38?,39+,40-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	175	n/a	n/a	n/a	n/a
KU Leuven Curated by ChEMBL					Assay Description Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium concentration				J Med Chem 52: 2933-9 (2009) Article DOI: 10.1021/jm9001007 BindingDB Entry DOI: 10.7270/Q27945K3
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