BDBM50278527 6-(piperidin-4-ylmethoxy)-2-naphthonitrile::CHEMBL469552
SMILES: N#Cc1ccc2cc(OCC3CCNCC3)ccc2c1
InChI Key: InChIKey=SHJHTXWKDLOBQS-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM50278527 (6-(piperidin-4-ylmethoxy)-2-naphthonitrile | CHEMB...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Inhibition of radiolabeled serotonin reuptake at human SERT expressed in HEK293 cells | Bioorg Med Chem Lett 19: 2329-32 (2009) Article DOI: 10.1016/j.bmcl.2009.02.054 BindingDB Entry DOI: 10.7270/Q2251J39 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Homo sapiens (Human)) | BDBM50278527 (6-(piperidin-4-ylmethoxy)-2-naphthonitrile | CHEMB...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Inhibition of radiolabeled dopamine reuptake at human DAT expressed in HEK293 cells | Bioorg Med Chem Lett 19: 2329-32 (2009) Article DOI: 10.1016/j.bmcl.2009.02.054 BindingDB Entry DOI: 10.7270/Q2251J39 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent noradrenaline transporter (Homo sapiens (Human)) | BDBM50278527 (6-(piperidin-4-ylmethoxy)-2-naphthonitrile | CHEMB...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Inhibition of radiolabeled noradrenaline reuptake at human NET expressed in HEK293 cells | Bioorg Med Chem Lett 19: 2329-32 (2009) Article DOI: 10.1016/j.bmcl.2009.02.054 BindingDB Entry DOI: 10.7270/Q2251J39 | |||||||||||
More data for this Ligand-Target Pair |