BDBM50278562 1-(2-(6-fluoronaphthalen-2-yl)ethyl)piperazine::CHEMBL465515
SMILES: Fc1ccc2cc(CCN3CCNCC3)ccc2c1
InChI Key: InChIKey=AVSJNVNTDDYDEP-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM50278562 (1-(2-(6-fluoronaphthalen-2-yl)ethyl)piperazine | C...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 8.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement of [3H]dofetilide from human ERG expressed in HEK293 cells | Bioorg Med Chem Lett 19: 2329-32 (2009) Article DOI: 10.1016/j.bmcl.2009.02.054 BindingDB Entry DOI: 10.7270/Q2251J39 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Homo sapiens (Human)) | BDBM50278562 (1-(2-(6-fluoronaphthalen-2-yl)ethyl)piperazine | C...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Inhibition of radiolabeled dopamine reuptake at human DAT expressed in HEK293 cells | Bioorg Med Chem Lett 19: 2329-32 (2009) Article DOI: 10.1016/j.bmcl.2009.02.054 BindingDB Entry DOI: 10.7270/Q2251J39 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM50278562 (1-(2-(6-fluoronaphthalen-2-yl)ethyl)piperazine | C...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Inhibition of radiolabeled serotonin reuptake at human SERT expressed in HEK293 cells | Bioorg Med Chem Lett 19: 2329-32 (2009) Article DOI: 10.1016/j.bmcl.2009.02.054 BindingDB Entry DOI: 10.7270/Q2251J39 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent noradrenaline transporter (Homo sapiens (Human)) | BDBM50278562 (1-(2-(6-fluoronaphthalen-2-yl)ethyl)piperazine | C...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.05E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Inhibition of radiolabeled noradrenaline reuptake at human NET expressed in HEK293 cells | Bioorg Med Chem Lett 19: 2329-32 (2009) Article DOI: 10.1016/j.bmcl.2009.02.054 BindingDB Entry DOI: 10.7270/Q2251J39 | |||||||||||
More data for this Ligand-Target Pair |