Found 7 hits for monomerid = 50278718 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50278718
(CHEMBL4171158)Show SMILES CCC(=O)N1CC[C@@H](C1)Oc1ncnc2CCN(Cc12)c1ccc(OC)nc1 |r| Show InChI InChI=1S/C20H25N5O3/c1-3-19(26)25-8-6-15(11-25)28-20-16-12-24(9-7-17(16)22-13-23-20)14-4-5-18(27-2)21-10-14/h4-5,10,13,15H,3,6-9,11-12H2,1-2H3/t15-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of recombinant human myristoylated PI3Kbeta catalytic domain expressed in Rat1 cells assessed as reduction in Akt phosphorylation at Ser47... |
ACS Med Chem Lett 8: 975-980 (2017)
Article DOI: 10.1021/acsmedchemlett.7b00293 BindingDB Entry DOI: 10.7270/Q2SX6GR0 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50278718
(CHEMBL4171158)Show SMILES CCC(=O)N1CC[C@@H](C1)Oc1ncnc2CCN(Cc12)c1ccc(OC)nc1 |r| Show InChI InChI=1S/C20H25N5O3/c1-3-19(26)25-8-6-15(11-25)28-20-16-12-24(9-7-17(16)22-13-23-20)14-4-5-18(27-2)21-10-14/h4-5,10,13,15H,3,6-9,11-12H2,1-2H3/t15-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description In vitro inhibition of human platelet aggregation induced by alpha-thrombin (at a concentration of 0.15 nM) |
ACS Med Chem Lett 8: 975-980 (2017)
Article DOI: 10.1021/acsmedchemlett.7b00293 BindingDB Entry DOI: 10.7270/Q2SX6GR0 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50278718
(CHEMBL4171158)Show SMILES CCC(=O)N1CC[C@@H](C1)Oc1ncnc2CCN(Cc12)c1ccc(OC)nc1 |r| Show InChI InChI=1S/C20H25N5O3/c1-3-19(26)25-8-6-15(11-25)28-20-16-12-24(9-7-17(16)22-13-23-20)14-4-5-18(27-2)21-10-14/h4-5,10,13,15H,3,6-9,11-12H2,1-2H3/t15-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.39E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description In vitro inhibition of human platelet aggregation induced by SFLLRN-NH2 (at a concentration of 2 uM) |
ACS Med Chem Lett 8: 975-980 (2017)
Article DOI: 10.1021/acsmedchemlett.7b00293 BindingDB Entry DOI: 10.7270/Q2SX6GR0 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50278718
(CHEMBL4171158)Show SMILES CCC(=O)N1CC[C@@H](C1)Oc1ncnc2CCN(Cc12)c1ccc(OC)nc1 |r| Show InChI InChI=1S/C20H25N5O3/c1-3-19(26)25-8-6-15(11-25)28-20-16-12-24(9-7-17(16)22-13-23-20)14-4-5-18(27-2)21-10-14/h4-5,10,13,15H,3,6-9,11-12H2,1-2H3/t15-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8.94E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of recombinant human myristoylated PI3Kbeta catalytic domain expressed in Rat1 cells assessed as reduction in Akt phosphorylation at Ser47... |
ACS Med Chem Lett 8: 975-980 (2017)
Article DOI: 10.1021/acsmedchemlett.7b00293 BindingDB Entry DOI: 10.7270/Q2SX6GR0 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50278718
(CHEMBL4171158)Show SMILES CCC(=O)N1CC[C@@H](C1)Oc1ncnc2CCN(Cc12)c1ccc(OC)nc1 |r| Show InChI InChI=1S/C20H25N5O3/c1-3-19(26)25-8-6-15(11-25)28-20-16-12-24(9-7-17(16)22-13-23-20)14-4-5-18(27-2)21-10-14/h4-5,10,13,15H,3,6-9,11-12H2,1-2H3/t15-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >9.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of PI3Kgamma (unknown origin) using phosphatidyl inositol as substrate measured after 30 mins by Alexa Fluor647-labelled ADP tracer based ... |
ACS Med Chem Lett 8: 975-980 (2017)
Article DOI: 10.1021/acsmedchemlett.7b00293 BindingDB Entry DOI: 10.7270/Q2SX6GR0 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50278718
(CHEMBL4171158)Show SMILES CCC(=O)N1CC[C@@H](C1)Oc1ncnc2CCN(Cc12)c1ccc(OC)nc1 |r| Show InChI InChI=1S/C20H25N5O3/c1-3-19(26)25-8-6-15(11-25)28-20-16-12-24(9-7-17(16)22-13-23-20)14-4-5-18(27-2)21-10-14/h4-5,10,13,15H,3,6-9,11-12H2,1-2H3/t15-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.66E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of recombinant human myristoylated PI3Kalpha catalytic domain expressed in Rat1 cells assessed as reduction in Akt phosphorylation at Ser4... |
ACS Med Chem Lett 8: 975-980 (2017)
Article DOI: 10.1021/acsmedchemlett.7b00293 BindingDB Entry DOI: 10.7270/Q2SX6GR0 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50278718
(CHEMBL4171158)Show SMILES CCC(=O)N1CC[C@@H](C1)Oc1ncnc2CCN(Cc12)c1ccc(OC)nc1 |r| Show InChI InChI=1S/C20H25N5O3/c1-3-19(26)25-8-6-15(11-25)28-20-16-12-24(9-7-17(16)22-13-23-20)14-4-5-18(27-2)21-10-14/h4-5,10,13,15H,3,6-9,11-12H2,1-2H3/t15-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 132 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of PI3Kdelta (unknown origin) using phosphatidyl inositol as substrate measured after 60 mins by Alexa Fluor647-labelled ADP tracer based ... |
ACS Med Chem Lett 8: 975-980 (2017)
Article DOI: 10.1021/acsmedchemlett.7b00293 BindingDB Entry DOI: 10.7270/Q2SX6GR0 |
More data for this Ligand-Target Pair | |