BDBM50279253 CHEMBL4176936

SMILES: CC1CCCCCCCC(=O)N(Cc2ccc(OCc3ccc(Cl)c(Cl)c3)cc2)C(c2c([nH]c3cc(Cl)ccc23)C(O)=O)C(=O)N1

InChI Key: InChIKey=UFAQNLRFERYSFN-UHFFFAOYSA-N

Data: 1 KI

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50279253   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MDM2-MDMX (Homo sapiens (Human))	BDBM50279253 (CHEMBL4176936) Show SMILES CC1CCCCCCCC(=O)N(Cc2ccc(OCc3ccc(Cl)c(Cl)c3)cc2)C(c2c([nH]c3cc(Cl)ccc23)C(O)=O)C(=O)N1 Show InChI InChI=1S/C35H36Cl3N3O5/c1-21-7-5-3-2-4-6-8-30(42)41(19-22-9-13-25(14-10-22)46-20-23-11-16-27(37)28(38)17-23)33(34(43)39-21)31-26-15-12-24(36)18-29(26)40-32(31)35(44)45/h9-18,21,33,40H,2-8,19-20H2,1H3,(H,39,43)(H,44,45)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	320	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Displacement of 5'FAM-LTFEHYWAQLTS from recombinant human N-terminal MDM2 (1 to 118 residues) expressed in Escherichia coli BL21-CodonPlus(DE3)-RIL a...				ACS Med Chem Lett 8: 1025-1030 (2017) Article DOI: 10.1021/acsmedchemlett.7b00219 BindingDB Entry DOI: 10.7270/Q2TQ6424
					More data for this Ligand-Target Pair