BDBM50279584 CHEMBL485694::N-[(1S,2S,4R,5R)-5-Guanidino-2,4-bis-(4-guanidino-phenoxy)-cyclohexyl]-guanidine
SMILES: [#7]\[#6](-[#7])=[#7]\[#6@@H]-1-[#6]-[#6@H](\[#7]=[#6](\[#7])-[#7])-[#6@H](-[#6]-[#6@H]1-[#8]-c1ccc(cc1)\[#7]=[#6](\[#7])-[#7])-[#8]-c1ccc(cc1)\[#7]=[#6](\[#7])-[#7]
InChI Key: InChIKey=MBDMLDIYZDMGFF-USTZCAOPSA-N
Data: 1 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA (Homo sapiens (Human)) | BDBM50279584 (CHEMBL485694 | N-[(1S,2S,4R,5R)-5-Guanidino-2,4-bi...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Mahidol University Curated by ChEMBL | Assay Description Inhibition of human recombinant furin-dependent anthrax protective antigen processing | Eur J Med Chem 44: 1664-73 (2009) Article DOI: 10.1016/j.ejmech.2008.09.028 BindingDB Entry DOI: 10.7270/Q2MK6CQ9 | |||||||||||
More data for this Ligand-Target Pair |